FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3134972904> ?p ?o ?g. }

• W3134972904 endingPage "153406" @default.
• W3134972904 startingPage "153406" @default.
• W3134972904 abstract "Gut-associated lymphoid tissue (GALT) carcinoma is a colorectal neoplasm characterized by cystically dilated neoplastic glands that extend into prominent, well-circumscribed submucosal lymphoid tissue. Although often subtle, lamina propria between and around the neoplastic glands (identified by plasma cells, scattered eosinophils, etc.) is frequent in cases with classic morphology, arguing (at least in such cases) in favor of adenoma extending into lymphoglandular complexes rather than true invasive carcinoma. Some have postulated that the tumor arises from M-cells, specialized epithelial cells overlying GALT, and others have suggested it represents a unique pathway to carcinoma, specific to the environmental conditions of epithelium overlying lymphoid tissue. Although both hypotheses are intriguing, definitive phenotypic and genetic support is currently lacking. To address these possibilities, we undertook whole exome sequencing and immunohistochemical characterization of a GALT neoplasm recently identified on our clinical service. We discovered well-known mutations in both APC and KRAS, as well as mutations in several Wnt pathway components (MED12, BCL9L, RFX4, DACT3). No immunohistochemical expression of GP2, a marker of M-cell differentiation, was identified. Expression of CDX2, SATB2, and the DNA mismatch repair proteins was observed, while expression of both CK7 and CK20 was absent. No PD-L1 expression was present on tumor cells, but PD-L1 expression was noted in a subset of tumor-adjacent mononuclear cells. Overall, the findings suggest that GALT neoplasms, although morphologically distinct, may be a precursor or early form of typical sporadic colon carcinoma." @default.
• W3134972904 created "2021-03-15" @default.
• W3134972904 creator A5001102076 @default.
• W3134972904 creator A5009197545 @default.
• W3134972904 creator A5029980353 @default.
• W3134972904 creator A5047690257 @default.
• W3134972904 creator A5061878287 @default.
• W3134972904 creator A5083630497 @default.
• W3134972904 date "2021-04-01" @default.
• W3134972904 modified "2023-10-01" @default.
• W3134972904 title "Whole exome sequencing of a gut-associated lymphoid tissue neoplasm points to precursor or early form of sporadic colon carcinoma" @default.
• W3134972904 cites W1534270394 @default.
• W3134972904 cites W1970413157 @default.
• W3134972904 cites W1998340711 @default.
• W3134972904 cites W2001712372 @default.
• W3134972904 cites W2003111539 @default.
• W3134972904 cites W2026083990 @default.
• W3134972904 cites W2034820020 @default.
• W3134972904 cites W2035795135 @default.
• W3134972904 cites W2036146068 @default.
• W3134972904 cites W2036897871 @default.
• W3134972904 cites W2038188490 @default.
• W3134972904 cites W2059145105 @default.
• W3134972904 cites W2085971602 @default.
• W3134972904 cites W2094122486 @default.
• W3134972904 cites W2101305463 @default.
• W3134972904 cites W2107696578 @default.
• W3134972904 cites W2108984616 @default.
• W3134972904 cites W2132123037 @default.
• W3134972904 cites W2137886330 @default.
• W3134972904 cites W2145948045 @default.
• W3134972904 cites W2160147327 @default.
• W3134972904 cites W2173732482 @default.
• W3134972904 cites W2188634560 @default.
• W3134972904 cites W2740259990 @default.
• W3134972904 cites W2795622837 @default.
• W3134972904 cites W2796153225 @default.
• W3134972904 cites W2800920802 @default.
• W3134972904 cites W2898402099 @default.
• W3134972904 cites W2898789672 @default.
• W3134972904 cites W2900359059 @default.
• W3134972904 cites W2939134067 @default.
• W3134972904 cites W2980933209 @default.
• W3134972904 cites W3136918052 @default.
• W3134972904 cites W4238448376 @default.
• W3134972904 cites W4240237951 @default.
• W3134972904 cites W4241505457 @default.
• W3134972904 cites W4294216483 @default.
• W3134972904 doi "https://doi.org/10.1016/j.prp.2021.153406" @default.
• W3134972904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33740545" @default.
• W3134972904 hasPublicationYear "2021" @default.
• W3134972904 type Work @default.
• W3134972904 sameAs 3134972904 @default.
• W3134972904 citedByCount "1" @default.
• W3134972904 countsByYear W31349729042023 @default.
• W3134972904 crossrefType "journal-article" @default.
• W3134972904 hasAuthorship W3134972904A5001102076 @default.
• W3134972904 hasAuthorship W3134972904A5009197545 @default.
• W3134972904 hasAuthorship W3134972904A5029980353 @default.
• W3134972904 hasAuthorship W3134972904A5047690257 @default.
• W3134972904 hasAuthorship W3134972904A5061878287 @default.
• W3134972904 hasAuthorship W3134972904A5083630497 @default.
• W3134972904 hasConcept C104317684 @default.
• W3134972904 hasConcept C121608353 @default.
• W3134972904 hasConcept C127716648 @default.
• W3134972904 hasConcept C142724271 @default.
• W3134972904 hasConcept C16671776 @default.
• W3134972904 hasConcept C181152851 @default.
• W3134972904 hasConcept C203014093 @default.
• W3134972904 hasConcept C204232928 @default.
• W3134972904 hasConcept C2777310793 @default.
• W3134972904 hasConcept C2779088137 @default.
• W3134972904 hasConcept C2780635560 @default.
• W3134972904 hasConcept C2781187634 @default.
• W3134972904 hasConcept C502942594 @default.
• W3134972904 hasConcept C526805850 @default.
• W3134972904 hasConcept C529295009 @default.
• W3134972904 hasConcept C54355233 @default.
• W3134972904 hasConcept C71924100 @default.
• W3134972904 hasConcept C86803240 @default.
• W3134972904 hasConceptScore W3134972904C104317684 @default.
• W3134972904 hasConceptScore W3134972904C121608353 @default.
• W3134972904 hasConceptScore W3134972904C127716648 @default.
• W3134972904 hasConceptScore W3134972904C142724271 @default.
• W3134972904 hasConceptScore W3134972904C16671776 @default.
• W3134972904 hasConceptScore W3134972904C181152851 @default.
• W3134972904 hasConceptScore W3134972904C203014093 @default.
• W3134972904 hasConceptScore W3134972904C204232928 @default.
• W3134972904 hasConceptScore W3134972904C2777310793 @default.
• W3134972904 hasConceptScore W3134972904C2779088137 @default.
• W3134972904 hasConceptScore W3134972904C2780635560 @default.
• W3134972904 hasConceptScore W3134972904C2781187634 @default.
• W3134972904 hasConceptScore W3134972904C502942594 @default.
• W3134972904 hasConceptScore W3134972904C526805850 @default.
• W3134972904 hasConceptScore W3134972904C529295009 @default.
• W3134972904 hasConceptScore W3134972904C54355233 @default.
• W3134972904 hasConceptScore W3134972904C71924100 @default.
• W3134972904 hasConceptScore W3134972904C86803240 @default.

• next