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- W3134986543 abstract "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) first emerged in December 2019 and spread quickly causing the coronavirus disease 2019 (COVID-19) pandemic. Recent single cell RNA-Seq analyses have shown the presence of SARS-CoV-2 entry factors in the human corneal, limbal, and conjunctival superficial epithelium, leading to suggestions that the human ocular surface may serve as an additional entry gateway and infection hub for SARS-CoV-2. In this article, we review the ocular clinical presentations of COVID-19 and the features of the ocular surface that may underline the overall low ocular SARS-CoV-2 infection. We critically evaluate the studies performed in nonhuman primates, ex vivo organ culture ocular models, stem cell derived eye organoids and the differences in infection efficiency observed in different parts of human ocular surface epithelium. Finally, we highlight the additional work that needs to be carried out to understand the immune response of the ocular surface to SARS-CoV-2 infection, which can be translated into prophylactic treatments that may be applied to other organ systems." @default.
- W3134986543 created "2021-03-15" @default.
- W3134986543 creator A5012252844 @default.
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- W3134986543 creator A5049869608 @default.
- W3134986543 creator A5058185135 @default.
- W3134986543 creator A5064384359 @default.
- W3134986543 date "2021-03-12" @default.
- W3134986543 modified "2023-09-24" @default.
- W3134986543 title "In the eye of the storm: <scp>SARS‐CoV‐2</scp> infection and replication at the ocular surface?" @default.
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- W3134986543 doi "https://doi.org/10.1002/sctm.20-0543" @default.
- W3134986543 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8235146" @default.
- W3134986543 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33710758" @default.