FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3134989984> ?p ?o ?g. }

• W3134989984 abstract "Neonatal calf diarrhea is a common disease leading to a major economic loss for cattle producers worldwide. Several infectious and noninfectious factors are implicated in calf diarrhea, but disease control remains problematic because of the multifactorial etiology of the disease. Here, we conducted diagnostic multiplex PCR assay and meta-omics analysis (16S rRNA gene-based metataxonomics and untargeted transcriptional profiling) of rectal content of normal and diarrheic beef calves (n = 111). In the diarrheic calf gut, we detected both microbial compositional dysbiosis (i.e., increased abundances of the family Enterobacteriaceae members and their lytic bacteriophages) and functional dysbiosis (i.e., elevated levels of aerobic respiration and virulence potential). The calf diarrheic transcriptome mirrored the gene expression of the bovine host and was enriched in cellular pathways of sulfur metabolism, innate immunity, and gut motility. We then isolated 12 nontoxigenic Enterobacteriaceae strains from the gut of diarrheic calves. Feeding a strain mixture to preweaning mice resulted in a significantly higher level of fecal moisture content, with decreased body weight gain and shortened colon length. The presented findings suggest that gut inflammation followed by a prolonged expansion of nontoxigenic autochthonous Enterobacteriaceae contributes to the onset of diarrhea in preweaning animals.IMPORTANCE Calf diarrhea is the leading cause of death of neonatal calves worldwide. Several infectious and noninfectious factors are implicated in calf diarrhea, but disease control remains problematic because of the multifactorial etiology of the disease. The major finding of the current study centers around the observation of microbial compositional and functional dysbiosis in rectal samples from diarrheic calves. These results highlight the notion that gut inflammation followed by a prolonged expansion of autochthonous Enterobacteriaceae contributes to the onset of calf diarrhea. Moreover, this condition possibly potentiates the risk of invasion of notorious enteric pathogens, including Salmonella spp., and the emergence of inflammation-resistant (or antibiotic-resistant) microbiota via active horizontal gene transfer mediated by lytic bacteriophages." @default.
• W3134989984 created "2021-03-15" @default.
• W3134989984 creator A5004832097 @default.
• W3134989984 creator A5012042594 @default.
• W3134989984 creator A5028070594 @default.
• W3134989984 creator A5046286922 @default.
• W3134989984 creator A5049620316 @default.
• W3134989984 creator A5050761087 @default.
• W3134989984 creator A5051195268 @default.
• W3134989984 creator A5060665695 @default.
• W3134989984 creator A5062140891 @default.
• W3134989984 creator A5074474550 @default.
• W3134989984 creator A5078699446 @default.
• W3134989984 creator A5078901131 @default.
• W3134989984 creator A5085965148 @default.
• W3134989984 date "2021-04-27" @default.
• W3134989984 modified "2023-10-18" @default.
• W3134989984 title "Calf Diarrhea Caused by Prolonged Expansion of Autochthonous Gut <i>Enterobacteriaceae</i> and Their Lytic Bacteriophages" @default.
• W3134989984 cites W1202512681 @default.
• W3134989984 cites W122717592 @default.
• W3134989984 cites W1558097999 @default.
• W3134989984 cites W1630001284 @default.
• W3134989984 cites W1647551795 @default.
• W3134989984 cites W1832474145 @default.
• W3134989984 cites W1860937064 @default.
• W3134989984 cites W1906208562 @default.
• W3134989984 cites W1926318014 @default.
• W3134989984 cites W1970609407 @default.
• W3134989984 cites W1978643679 @default.
• W3134989984 cites W1983320630 @default.
• W3134989984 cites W1986709953 @default.
• W3134989984 cites W1989014451 @default.
• W3134989984 cites W1989130597 @default.
• W3134989984 cites W1990379298 @default.
• W3134989984 cites W1994600122 @default.
• W3134989984 cites W2008194879 @default.
• W3134989984 cites W2008520672 @default.
• W3134989984 cites W2012606594 @default.
• W3134989984 cites W2016073955 @default.
• W3134989984 cites W2020629141 @default.
• W3134989984 cites W2026760689 @default.
• W3134989984 cites W2031893281 @default.
• W3134989984 cites W2034285706 @default.
• W3134989984 cites W2041944861 @default.
• W3134989984 cites W2044211201 @default.
• W3134989984 cites W2045204781 @default.
• W3134989984 cites W2046549547 @default.
• W3134989984 cites W2057327775 @default.
• W3134989984 cites W2068660198 @default.
• W3134989984 cites W2072970694 @default.
• W3134989984 cites W2076048958 @default.
• W3134989984 cites W2081319466 @default.
• W3134989984 cites W2093021153 @default.
• W3134989984 cites W2096497004 @default.
• W3134989984 cites W2096605667 @default.
• W3134989984 cites W2097557530 @default.
• W3134989984 cites W2100305481 @default.
• W3134989984 cites W2103549276 @default.
• W3134989984 cites W2103761010 @default.
• W3134989984 cites W2112852559 @default.
• W3134989984 cites W2124042319 @default.
• W3134989984 cites W2124799197 @default.
• W3134989984 cites W2127580313 @default.
• W3134989984 cites W2128601422 @default.
• W3134989984 cites W2131271579 @default.
• W3134989984 cites W2133856765 @default.
• W3134989984 cites W2140729960 @default.
• W3134989984 cites W2142176767 @default.
• W3134989984 cites W2144241990 @default.
• W3134989984 cites W2147887327 @default.
• W3134989984 cites W2153216300 @default.
• W3134989984 cites W2156602527 @default.
• W3134989984 cites W2158677776 @default.
• W3134989984 cites W2159861680 @default.
• W3134989984 cites W2168150136 @default.
• W3134989984 cites W2170551349 @default.
• W3134989984 cites W2171707827 @default.
• W3134989984 cites W2179438025 @default.
• W3134989984 cites W2186551313 @default.
• W3134989984 cites W2205261197 @default.
• W3134989984 cites W2271248844 @default.
• W3134989984 cites W2330035814 @default.
• W3134989984 cites W2337802775 @default.
• W3134989984 cites W2401404581 @default.
• W3134989984 cites W2466764366 @default.
• W3134989984 cites W2511883439 @default.
• W3134989984 cites W2597203121 @default.
• W3134989984 cites W2606690066 @default.
• W3134989984 cites W2610214149 @default.
• W3134989984 cites W2766358903 @default.
• W3134989984 cites W2776445964 @default.
• W3134989984 cites W2776695687 @default.
• W3134989984 cites W2777913435 @default.
• W3134989984 cites W2781836545 @default.
• W3134989984 cites W2790162428 @default.
• W3134989984 cites W2790367768 @default.
• W3134989984 cites W2897204056 @default.
• W3134989984 cites W4233698560 @default.
• W3134989984 cites W4296816736 @default.
• W3134989984 doi "https://doi.org/10.1128/msystems.00816-20" @default.

• next