Matches in SemOpenAlex for { <https://semopenalex.org/work/W3135020177> ?p ?o ?g. }
- W3135020177 abstract "Abstract Pressure injuries (PIs), also known as bedsores or pressure ulcers, are a major cause of death and morbidity in the elderly. The serine protease, Granzyme B (GzmB), contributes to skin aging and impaired wound healing. Aging is a major risk factor for PIs; thus, the role of GzmB in PI pathogenesis was investigated. GzmB levels in human PI tissue and wound fluids were markedly elevated. A causative role for GzmB was assessed in GzmB knockout (GzmB−/−) and wild-type (WT) mice using a murine model of PI. An apolipoprotein E knockout (ApoE−/−) model of aging and vascular dysfunction was also utilized to assess GzmB in a relevant age-related model better resembling tissue perfusion in the elderly. PI severity displayed no difference between young GzmB−/− and WT mice. However, in aged mice, PI severity was reduced in mice lacking GzmB. Mechanistically, GzmB increased vascular wall inflammation and impaired extracellular matrix remodeling. Together, GzmB is an important contributor to age-dependent impaired PI healing." @default.
- W3135020177 created "2021-03-15" @default.
- W3135020177 creator A5005991594 @default.
- W3135020177 creator A5009800934 @default.
- W3135020177 creator A5015532131 @default.
- W3135020177 creator A5018173253 @default.
- W3135020177 creator A5018398282 @default.
- W3135020177 creator A5025008383 @default.
- W3135020177 creator A5047443007 @default.
- W3135020177 creator A5050415963 @default.
- W3135020177 creator A5053986280 @default.
- W3135020177 creator A5076445777 @default.
- W3135020177 date "2021-03-05" @default.
- W3135020177 modified "2023-09-26" @default.
- W3135020177 title "Granzyme B mediates impaired healing of pressure injuries in aged skin" @default.
- W3135020177 cites W148753544 @default.
- W3135020177 cites W1800099715 @default.
- W3135020177 cites W1968796838 @default.
- W3135020177 cites W1969709506 @default.
- W3135020177 cites W1985105797 @default.
- W3135020177 cites W1988784569 @default.
- W3135020177 cites W1989727926 @default.
- W3135020177 cites W1992519413 @default.
- W3135020177 cites W2001830814 @default.
- W3135020177 cites W2018299480 @default.
- W3135020177 cites W2019309256 @default.
- W3135020177 cites W2021596920 @default.
- W3135020177 cites W2022387905 @default.
- W3135020177 cites W2023591516 @default.
- W3135020177 cites W2033605121 @default.
- W3135020177 cites W2035208235 @default.
- W3135020177 cites W2041673031 @default.
- W3135020177 cites W2048017617 @default.
- W3135020177 cites W2055467504 @default.
- W3135020177 cites W2076687077 @default.
- W3135020177 cites W2084542841 @default.
- W3135020177 cites W2095775431 @default.
- W3135020177 cites W2103674104 @default.
- W3135020177 cites W2132531216 @default.
- W3135020177 cites W2139921980 @default.
- W3135020177 cites W2152727043 @default.
- W3135020177 cites W2160307430 @default.
- W3135020177 cites W2165790227 @default.
- W3135020177 cites W2172394310 @default.
- W3135020177 cites W2735790845 @default.
- W3135020177 cites W2772277960 @default.
- W3135020177 cites W2894772070 @default.
- W3135020177 cites W2899646952 @default.
- W3135020177 cites W2904306940 @default.
- W3135020177 cites W2921224315 @default.
- W3135020177 doi "https://doi.org/10.1038/s41514-021-00059-6" @default.
- W3135020177 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7935969" @default.
- W3135020177 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33674592" @default.
- W3135020177 hasPublicationYear "2021" @default.
- W3135020177 type Work @default.
- W3135020177 sameAs 3135020177 @default.
- W3135020177 citedByCount "10" @default.
- W3135020177 countsByYear W31350201772021 @default.
- W3135020177 countsByYear W31350201772022 @default.
- W3135020177 countsByYear W31350201772023 @default.
- W3135020177 crossrefType "journal-article" @default.
- W3135020177 hasAuthorship W3135020177A5005991594 @default.
- W3135020177 hasAuthorship W3135020177A5009800934 @default.
- W3135020177 hasAuthorship W3135020177A5015532131 @default.
- W3135020177 hasAuthorship W3135020177A5018173253 @default.
- W3135020177 hasAuthorship W3135020177A5018398282 @default.
- W3135020177 hasAuthorship W3135020177A5025008383 @default.
- W3135020177 hasAuthorship W3135020177A5047443007 @default.
- W3135020177 hasAuthorship W3135020177A5050415963 @default.
- W3135020177 hasAuthorship W3135020177A5053986280 @default.
- W3135020177 hasAuthorship W3135020177A5076445777 @default.
- W3135020177 hasBestOaLocation W31350201771 @default.
- W3135020177 hasConcept C126322002 @default.
- W3135020177 hasConcept C167672396 @default.
- W3135020177 hasConcept C170493617 @default.
- W3135020177 hasConcept C182704531 @default.
- W3135020177 hasConcept C183193105 @default.
- W3135020177 hasConcept C203014093 @default.
- W3135020177 hasConcept C2776062744 @default.
- W3135020177 hasConcept C2776914184 @default.
- W3135020177 hasConcept C2780269544 @default.
- W3135020177 hasConcept C2780380082 @default.
- W3135020177 hasConcept C2780394083 @default.
- W3135020177 hasConcept C71924100 @default.
- W3135020177 hasConcept C8891405 @default.
- W3135020177 hasConceptScore W3135020177C126322002 @default.
- W3135020177 hasConceptScore W3135020177C167672396 @default.
- W3135020177 hasConceptScore W3135020177C170493617 @default.
- W3135020177 hasConceptScore W3135020177C182704531 @default.
- W3135020177 hasConceptScore W3135020177C183193105 @default.
- W3135020177 hasConceptScore W3135020177C203014093 @default.
- W3135020177 hasConceptScore W3135020177C2776062744 @default.
- W3135020177 hasConceptScore W3135020177C2776914184 @default.
- W3135020177 hasConceptScore W3135020177C2780269544 @default.
- W3135020177 hasConceptScore W3135020177C2780380082 @default.
- W3135020177 hasConceptScore W3135020177C2780394083 @default.
- W3135020177 hasConceptScore W3135020177C71924100 @default.
- W3135020177 hasConceptScore W3135020177C8891405 @default.
- W3135020177 hasIssue "1" @default.
- W3135020177 hasLocation W31350201771 @default.