FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3135020274> ?p ?o ?g. }

• W3135020274 abstract "Neutrophils or polymorphonuclear leukocytes (PMN) are key participants in the innate immune response for their ability to execute different effector functions. These cells express a vast array of membrane receptors that allow them to recognize and eliminate infectious agents effectively and respond appropriately to microenvironmental stimuli that regulate neutrophil functions, such as activation, migration, generation of reactive oxygen species, formation of neutrophil extracellular traps, and mediator secretion, among others. Currently, it has been realized that activated neutrophils can accomplish their effector functions and simultaneously activate mechanisms of cell death in response to different intracellular or extracellular factors. Although several studies have revealed similarities between the mechanisms of cell death of neutrophils and other cell types, neutrophils have distinctive properties, such as a high production of reactive oxygen species (ROS) and nitrogen species (RNS), that are important for their effector function in infections and pathologies such as cancer, autoimmune diseases, and immunodeficiencies, influencing their cell death mechanisms. The present work offers a synthesis of the conditions and molecules implicated in the regulation and activation of the processes of neutrophil death: apoptosis, autophagy, pyroptosis, necroptosis, NETosis, and necrosis. This information allows to understand the duality encountered by PMNs upon activation. The effector functions are carried out to eliminate invading pathogens, but in several instances, these functions involve activation of signaling cascades that culminate in the death of the neutrophil. This process guarantees the correct elimination of pathogenic agents, damaged or senescent cells, and the timely resolution of the inflammation that is essential for the maintenance of homeostasis in the organism. In addition, they alert the organism when the immunological system is being deregulated, promoting the activation of other cells of the immune system, such as B and T lymphocytes, which produce cytokines that potentiate the microbicide functions." @default.
• W3135020274 created "2021-03-15" @default.
• W3135020274 creator A5001453197 @default.
• W3135020274 creator A5047534007 @default.
• W3135020274 creator A5070581675 @default.
• W3135020274 creator A5083038211 @default.
• W3135020274 date "2021-03-04" @default.
• W3135020274 modified "2023-10-10" @default.
• W3135020274 title "Neutrophils: Many Ways to Die" @default.
• W3135020274 cites W146301169 @default.
• W3135020274 cites W1483739722 @default.
• W3135020274 cites W1489363264 @default.
• W3135020274 cites W1495110150 @default.
• W3135020274 cites W1505835018 @default.
• W3135020274 cites W1506145586 @default.
• W3135020274 cites W1509198290 @default.
• W3135020274 cites W1537725978 @default.
• W3135020274 cites W1539508455 @default.
• W3135020274 cites W1579159738 @default.
• W3135020274 cites W1585536154 @default.
• W3135020274 cites W1595587273 @default.
• W3135020274 cites W1600560134 @default.
• W3135020274 cites W1602238325 @default.
• W3135020274 cites W1614698054 @default.
• W3135020274 cites W1633821840 @default.
• W3135020274 cites W1662325488 @default.
• W3135020274 cites W1681184579 @default.
• W3135020274 cites W1857408336 @default.
• W3135020274 cites W1860481694 @default.
• W3135020274 cites W1870984232 @default.
• W3135020274 cites W1890441729 @default.
• W3135020274 cites W1906542005 @default.
• W3135020274 cites W1914390290 @default.
• W3135020274 cites W1915121024 @default.
• W3135020274 cites W1916796423 @default.
• W3135020274 cites W1939466806 @default.
• W3135020274 cites W1951140057 @default.
• W3135020274 cites W1964182229 @default.
• W3135020274 cites W1965013629 @default.
• W3135020274 cites W1966678873 @default.
• W3135020274 cites W1967239224 @default.
• W3135020274 cites W1967912613 @default.
• W3135020274 cites W1968295892 @default.
• W3135020274 cites W1968442371 @default.
• W3135020274 cites W1968813300 @default.
• W3135020274 cites W1969312210 @default.
• W3135020274 cites W1972708772 @default.
• W3135020274 cites W1973336682 @default.
• W3135020274 cites W1973628719 @default.
• W3135020274 cites W1976782874 @default.
• W3135020274 cites W1977832237 @default.
• W3135020274 cites W1979166122 @default.
• W3135020274 cites W1980668692 @default.
• W3135020274 cites W1981028832 @default.
• W3135020274 cites W1981176905 @default.
• W3135020274 cites W1981397556 @default.
• W3135020274 cites W1981855430 @default.
• W3135020274 cites W1983189342 @default.
• W3135020274 cites W1983425628 @default.
• W3135020274 cites W1984520240 @default.
• W3135020274 cites W1984848905 @default.
• W3135020274 cites W1985970823 @default.
• W3135020274 cites W1986282241 @default.
• W3135020274 cites W1986283558 @default.
• W3135020274 cites W1987186266 @default.
• W3135020274 cites W1989739325 @default.
• W3135020274 cites W1991300803 @default.
• W3135020274 cites W1992213437 @default.
• W3135020274 cites W1992815676 @default.
• W3135020274 cites W1996083893 @default.
• W3135020274 cites W1996912053 @default.
• W3135020274 cites W1997582352 @default.
• W3135020274 cites W1997839876 @default.
• W3135020274 cites W1998423564 @default.
• W3135020274 cites W2000279714 @default.
• W3135020274 cites W2000415422 @default.
• W3135020274 cites W2001447621 @default.
• W3135020274 cites W2003605139 @default.
• W3135020274 cites W2003758590 @default.
• W3135020274 cites W2004536682 @default.
• W3135020274 cites W2005222767 @default.
• W3135020274 cites W2006679777 @default.
• W3135020274 cites W2007982299 @default.
• W3135020274 cites W2008391022 @default.
• W3135020274 cites W2008605768 @default.
• W3135020274 cites W2011476001 @default.
• W3135020274 cites W2011670785 @default.
• W3135020274 cites W2013109381 @default.
• W3135020274 cites W2013183753 @default.
• W3135020274 cites W2013715338 @default.
• W3135020274 cites W2014678245 @default.
• W3135020274 cites W2014776493 @default.
• W3135020274 cites W2015387286 @default.
• W3135020274 cites W2016391141 @default.
• W3135020274 cites W2018536993 @default.
• W3135020274 cites W2019552956 @default.
• W3135020274 cites W2022699678 @default.
• W3135020274 cites W2023122823 @default.
• W3135020274 cites W2026185907 @default.
• W3135020274 cites W2026384914 @default.

• next