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- W3135041809 abstract "Tumor-associated macrophages (TAMs) promote the immune suppressive microenvironment inside tumors and are, therefore, considered as a promising target for the next generation of cancer immunotherapies. To repolarize their phenotype into a tumoricidal state, the Toll-like receptor 7/8 agonist imidazoquinoline IMDQ is site-specifically and quantitatively coupled to single chain antibody fragments, so-called nanobodies, targeting the macrophage mannose receptor (MMR) on TAMs. Intravenous injection of these conjugates result in a tumor- and cell-specific delivery of IMDQ into MMRhigh TAMs, causing a significant decline in tumor growth. This is accompanied by a repolarization of TAMs towards a pro-inflammatory phenotype and an increase in anti-tumor T cell responses. Therefore, the therapeutic benefit of such nanobody-drug conjugates may pave the road towards effective macrophage re-educating cancer immunotherapies." @default.
- W3135041809 created "2021-03-15" @default.
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- W3135041809 date "2021-03-08" @default.
- W3135041809 modified "2023-10-01" @default.
- W3135041809 title "Targeted Repolarization of Tumor‐Associated Macrophages via Imidazoquinoline‐Linked Nanobodies" @default.
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- W3135041809 doi "https://doi.org/10.1002/advs.202004574" @default.
- W3135041809 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8132149" @default.
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