Matches in SemOpenAlex for { <https://semopenalex.org/work/W3135059467> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W3135059467 endingPage "107499" @default.
- W3135059467 startingPage "107499" @default.
- W3135059467 abstract "ERBB2 is a well-studied oncogene that promotes progression of multiple cancers, especially in breast cancer. However, the expression status of ERBB2, the values of ERBB2 on prognosis, and its molecular characterization in glioma have not been well examined. We explored the expression of ERBB2 and its clinical and molecular immune characterization in human glioma samples using the extracted genetic and clinical data from the Cancer Genome Atlas (TCGA) and the Chinese Glioma Genome Atlas (CGGA) databases. Immunohistochemistry (IHC) performed on the tissue microarray slide was used to validate the expression and clinical and prognostic values of ERBB2 in glioma. Higher ERBB2 expression was found in patients with higher grades gliomas than in patients with lower grades gliomas. Besides, patients with higher ERBB2 expression showed poor prognosis. The IHC and clinical data next validated the expression pattern and prognostic value of ERBB2 in glioma. Further analysis showed that there was a strong positive correlation between ERBB2 and common immune checkpoints as well as immune markers of various immune cells in both TCGA and CGGA databases, and the IHC data further validated the positive correlation between ERBB2 and PD-L1 expression. Besides, analysis of ERBB2-related immune genes and signatures showed the significant role of ERBB2 in mediating tumor immune response in glioma. To sum up, our findings summarize the expression pattern and clinical characteristics of ERBB2 in glioma, which may be useful for expanding our understanding of the critical role of ERBB2 in antitumor therapy in glioma." @default.
- W3135059467 created "2021-03-15" @default.
- W3135059467 creator A5013365903 @default.
- W3135059467 creator A5059082021 @default.
- W3135059467 creator A5074504754 @default.
- W3135059467 creator A5084548928 @default.
- W3135059467 creator A5087287319 @default.
- W3135059467 date "2021-05-01" @default.
- W3135059467 modified "2023-09-26" @default.
- W3135059467 title "Clinical and molecular immune characterization of ERBB2 in glioma" @default.
- W3135059467 cites W1838685504 @default.
- W3135059467 cites W1967827870 @default.
- W3135059467 cites W2037690883 @default.
- W3135059467 cites W2037831349 @default.
- W3135059467 cites W2056579307 @default.
- W3135059467 cites W2056660201 @default.
- W3135059467 cites W2058836795 @default.
- W3135059467 cites W2070727232 @default.
- W3135059467 cites W2138523273 @default.
- W3135059467 cites W2160382843 @default.
- W3135059467 cites W2192976324 @default.
- W3135059467 cites W2403175291 @default.
- W3135059467 cites W2566835536 @default.
- W3135059467 cites W2579492303 @default.
- W3135059467 cites W2600434382 @default.
- W3135059467 cites W2604606623 @default.
- W3135059467 cites W2614794838 @default.
- W3135059467 cites W2803147243 @default.
- W3135059467 cites W2912676825 @default.
- W3135059467 cites W2944437672 @default.
- W3135059467 cites W2962838796 @default.
- W3135059467 cites W3016592472 @default.
- W3135059467 cites W3035540747 @default.
- W3135059467 cites W3118649141 @default.
- W3135059467 cites W4247435334 @default.
- W3135059467 doi "https://doi.org/10.1016/j.intimp.2021.107499" @default.
- W3135059467 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33640859" @default.
- W3135059467 hasPublicationYear "2021" @default.
- W3135059467 type Work @default.
- W3135059467 sameAs 3135059467 @default.
- W3135059467 citedByCount "5" @default.
- W3135059467 countsByYear W31350594672021 @default.
- W3135059467 countsByYear W31350594672022 @default.
- W3135059467 countsByYear W31350594672023 @default.
- W3135059467 crossrefType "journal-article" @default.
- W3135059467 hasAuthorship W3135059467A5013365903 @default.
- W3135059467 hasAuthorship W3135059467A5059082021 @default.
- W3135059467 hasAuthorship W3135059467A5074504754 @default.
- W3135059467 hasAuthorship W3135059467A5084548928 @default.
- W3135059467 hasAuthorship W3135059467A5087287319 @default.
- W3135059467 hasConcept C121608353 @default.
- W3135059467 hasConcept C143998085 @default.
- W3135059467 hasConcept C203014093 @default.
- W3135059467 hasConcept C204232928 @default.
- W3135059467 hasConcept C2778227246 @default.
- W3135059467 hasConcept C2781018059 @default.
- W3135059467 hasConcept C29537977 @default.
- W3135059467 hasConcept C502942594 @default.
- W3135059467 hasConcept C54355233 @default.
- W3135059467 hasConcept C71924100 @default.
- W3135059467 hasConcept C86803240 @default.
- W3135059467 hasConcept C8891405 @default.
- W3135059467 hasConceptScore W3135059467C121608353 @default.
- W3135059467 hasConceptScore W3135059467C143998085 @default.
- W3135059467 hasConceptScore W3135059467C203014093 @default.
- W3135059467 hasConceptScore W3135059467C204232928 @default.
- W3135059467 hasConceptScore W3135059467C2778227246 @default.
- W3135059467 hasConceptScore W3135059467C2781018059 @default.
- W3135059467 hasConceptScore W3135059467C29537977 @default.
- W3135059467 hasConceptScore W3135059467C502942594 @default.
- W3135059467 hasConceptScore W3135059467C54355233 @default.
- W3135059467 hasConceptScore W3135059467C71924100 @default.
- W3135059467 hasConceptScore W3135059467C86803240 @default.
- W3135059467 hasConceptScore W3135059467C8891405 @default.
- W3135059467 hasFunder F4320313623 @default.
- W3135059467 hasFunder F4320324880 @default.
- W3135059467 hasFunder F4320327778 @default.
- W3135059467 hasLocation W31350594671 @default.
- W3135059467 hasOpenAccess W3135059467 @default.
- W3135059467 hasPrimaryLocation W31350594671 @default.
- W3135059467 hasRelatedWork W1104561468 @default.
- W3135059467 hasRelatedWork W2508252533 @default.
- W3135059467 hasRelatedWork W2732784745 @default.
- W3135059467 hasRelatedWork W2768051262 @default.
- W3135059467 hasRelatedWork W2770333794 @default.
- W3135059467 hasRelatedWork W2792929645 @default.
- W3135059467 hasRelatedWork W2902203810 @default.
- W3135059467 hasRelatedWork W2988175535 @default.
- W3135059467 hasRelatedWork W3127218133 @default.
- W3135059467 hasRelatedWork W3005931108 @default.
- W3135059467 hasVolume "94" @default.
- W3135059467 isParatext "false" @default.
- W3135059467 isRetracted "false" @default.
- W3135059467 magId "3135059467" @default.
- W3135059467 workType "article" @default.