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• W3135081659 abstract "Exercise improves obesity-induced insulin resistance via mechanisms that remain unclear. The novel findings of the study are that circulating TTR (a hepatokine) level is decreased by exercise, and the elevated circulating TTR, as was the elevated transthyretin internalization mediated by Grp78, counteracts the exercise-induced insulin sensitivity by downregulating AMPK activity in skeletal muscle of obese mice. These data suggest that TTR suppression might be an adaptive response to exercise through the crosstalk between liver and muscle." @default.
• W3135081659 created "2021-03-15" @default.
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• W3135081659 date "2021-04-01" @default.
• W3135081659 modified "2023-09-24" @default.
• W3135081659 title "Transthyretin contributes to insulin resistance and diminishes exercise-induced insulin sensitivity in obese mice by inhibiting AMPK activity in skeletal muscle" @default.
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• W3135081659 doi "https://doi.org/10.1152/ajpendo.00495.2020" @default.
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