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- W3135134023 abstract "Purpose of review Multiple sclerosis (MS) is a clinically heterogeneous disease, which complicates expectant management as well as treatment decisions. This review provides an overview of both well established and emerging predictors of disability worsening, including clinical factors, imaging factors, biomarkers and treatment strategies. Recent findings In addition to well known clinical predictors (age, male sex, clinical presentation, relapse behaviour), smoking, obesity, vascular and psychiatric comorbidities are associated with subsequent disability worsening in persons with MS. A number of imaging features are predictive of disability worsening and are present to varying degrees in relapsing and progressive forms of MS. These include brain volumes, spinal cord atrophy, lesion volumes and optical coherence tomography features. Cerebrospinal and more recently blood biomarkers including neurofilament light show promise as more easily attainable biomarkers of future disability accumulation. Importantly, recent observational studies suggest that initiation of early-intensive therapy, as opposed to escalation based on breakthrough disease, is associated with decreased accumulation of disability overall, although randomized controlled trials investigating this question are underway. Summary Understanding risk factors associated with disability progression can help to both counsel patients and enhance the clinician's availability to provide evidence-based treatment recommendations." @default.
- W3135134023 created "2021-03-15" @default.
- W3135134023 creator A5015543357 @default.
- W3135134023 creator A5015754502 @default.
- W3135134023 creator A5035095164 @default.
- W3135134023 creator A5071972650 @default.
- W3135134023 date "2021-03-11" @default.
- W3135134023 modified "2023-09-26" @default.
- W3135134023 title "Predicting disability worsening in relapsing and progressive multiple sclerosis" @default.
- W3135134023 cites W1483072462 @default.
- W3135134023 cites W1572639874 @default.
- W3135134023 cites W1879602763 @default.
- W3135134023 cites W1944603265 @default.
- W3135134023 cites W1966515383 @default.
- W3135134023 cites W1968023538 @default.
- W3135134023 cites W1986878825 @default.
- W3135134023 cites W1992383729 @default.
- W3135134023 cites W2001684352 @default.
- W3135134023 cites W2012040225 @default.
- W3135134023 cites W2013370381 @default.
- W3135134023 cites W2015040716 @default.
- W3135134023 cites W2016524113 @default.
- W3135134023 cites W2016541162 @default.
- W3135134023 cites W2029817323 @default.
- W3135134023 cites W2030342005 @default.
- W3135134023 cites W2045680585 @default.
- W3135134023 cites W2080852206 @default.
- W3135134023 cites W2083869326 @default.
- W3135134023 cites W2086091627 @default.
- W3135134023 cites W2089608136 @default.
- W3135134023 cites W2106154122 @default.
- W3135134023 cites W2106933931 @default.
- W3135134023 cites W2108884281 @default.
- W3135134023 cites W2109752085 @default.
- W3135134023 cites W2112165124 @default.
- W3135134023 cites W2119408292 @default.
- W3135134023 cites W2125411015 @default.
- W3135134023 cites W2128584287 @default.
- W3135134023 cites W2132487252 @default.
- W3135134023 cites W2139344244 @default.
- W3135134023 cites W2142588971 @default.
- W3135134023 cites W2146853725 @default.
- W3135134023 cites W2148186809 @default.
- W3135134023 cites W2153266519 @default.
- W3135134023 cites W2158515030 @default.
- W3135134023 cites W2160099998 @default.
- W3135134023 cites W2164832046 @default.
- W3135134023 cites W2165184392 @default.
- W3135134023 cites W2170824762 @default.
- W3135134023 cites W2172431827 @default.
- W3135134023 cites W2178226309 @default.
- W3135134023 cites W2296989255 @default.
- W3135134023 cites W2325038063 @default.
- W3135134023 cites W2395769988 @default.
- W3135134023 cites W2474020503 @default.
- W3135134023 cites W2479632750 @default.
- W3135134023 cites W2514396275 @default.
- W3135134023 cites W2530962812 @default.
- W3135134023 cites W2561881161 @default.
- W3135134023 cites W2588292672 @default.
- W3135134023 cites W2588488142 @default.
- W3135134023 cites W2588929689 @default.
- W3135134023 cites W2589005373 @default.
- W3135134023 cites W2596982404 @default.
- W3135134023 cites W2614808368 @default.
- W3135134023 cites W2618279718 @default.
- W3135134023 cites W2619457510 @default.
- W3135134023 cites W2742808332 @default.
- W3135134023 cites W2752554587 @default.
- W3135134023 cites W2757438183 @default.
- W3135134023 cites W2766371671 @default.
- W3135134023 cites W2768602966 @default.
- W3135134023 cites W2791265204 @default.
- W3135134023 cites W2793736701 @default.
- W3135134023 cites W2802525182 @default.
- W3135134023 cites W2883501862 @default.
- W3135134023 cites W2884726359 @default.
- W3135134023 cites W2885695004 @default.
- W3135134023 cites W2886911907 @default.
- W3135134023 cites W2901936354 @default.
- W3135134023 cites W2906455140 @default.
- W3135134023 cites W2909612451 @default.
- W3135134023 cites W2910867209 @default.
- W3135134023 cites W2912898431 @default.
- W3135134023 cites W2916478209 @default.
- W3135134023 cites W2935754061 @default.
- W3135134023 cites W2942786854 @default.
- W3135134023 cites W2945631836 @default.
- W3135134023 cites W2949008890 @default.
- W3135134023 cites W2964809616 @default.
- W3135134023 cites W2965263041 @default.
- W3135134023 cites W2966185454 @default.
- W3135134023 cites W2967069002 @default.
- W3135134023 cites W2981288801 @default.
- W3135134023 cites W2987676206 @default.
- W3135134023 cites W2994990496 @default.
- W3135134023 cites W3001552075 @default.
- W3135134023 cites W3008600501 @default.