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• W3135139565 abstract "Abstract Secretory cargos are collected at ER exit sites (ERES) before transport to the Golgi apparatus. Decades of research have provided many details of the molecular events underlying ER-Golgi exchanges. Essential questions, however, remain about the organization of the ER-Golgi interface in cells and the type of membrane structures mediating traffic from ERES. To investigate these, we used transgenic tagging in Drosophila flies, 3D-SIM and FIB-SEM to characterize ERES-Golgi units in collagen-producing fat body, imaginal discs and imaginal discs overexpressing ERES determinant Tango1. We found in front of ERES a pre-cis-Golgi region involved in both anterograde and retrograde transport. This pre-cis-Golgi is continuous with the rest of the Golgi, not a separate intermediate compartment or collection of large carriers, for which we found no evidence. We found, however, many vesicles, as well as pearled tubules connecting ERES and Golgi." @default.
• W3135139565 created "2021-03-15" @default.
• W3135139565 creator A5012164869 @default.
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• W3135139565 creator A5076525253 @default.
• W3135139565 date "2021-03-09" @default.
• W3135139565 modified "2023-09-23" @default.
• W3135139565 title "ER exit sites in<i>Drosophila</i>display abundant ER-Golgi vesicles and pearled tubes but no megacarriers" @default.
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• W3135139565 doi "https://doi.org/10.1101/2021.03.09.434528" @default.
• W3135139565 hasPublicationYear "2021" @default.
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• W3135139565 hasAuthorship W3135139565A5017035217 @default.

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