FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3135154782> ?p ?o ?g. }

• W3135154782 endingPage "21790" @default.
• W3135154782 startingPage "21778" @default.
• W3135154782 abstract "We investigated the influence of signal transducer and activator of transcription-3 (STAT3) on the spinal cord tissue grafts of rat fetuses with spina bifida aperta. In particular, we hoped to identify whether transfection of the STAT3 overexpression plasmid increases the survival of spinal cord transplantation in order to improve therapeutic efficacy. The fetal rat model of spina bifida aperta was established using retinoic acid and treated with a microsurgical injection of bone marrow mesenchymal stem cells (BMSCs). The animals were divided into either the blank control group, negative control group or the experimental group. The optical density (OD) value of BMSCs viability was determined using the Cell Counting Kit-8 (CCK-8). The expression of STAT3, phosphorylated STAT3 (pSTAT3), neural markers and apoptosis-related factors were evaluated using real-time PCR and Western blot. The OD value in the experimental group was highest at eight hours after transplantation using CCK-8. The expression of pSTAT3, glial fibrillary acidic protein, neuron-specific enolase, neurofilament and nestin in the experimental group was significantly higher compared to the blank control group and negative control group (P<0.05). However, STAT3 expression in the experimental group was statistically significantly decreased (P<0.05). The relative expression of caspase-8 and bcl-2 in the experimental group were significantly lower compared to the blank control group and negative control group (P<0.05). Transfection of the recombinant lentivirus-mediated STAT3 overexpression plasmid with BMSCs can help improve the efficiency of transforming into neural cells and provide new seed cells for the treatment of congenital spina bifida aperta." @default.
• W3135154782 created "2021-03-15" @default.
• W3135154782 creator A5001208053 @default.
• W3135154782 creator A5001544145 @default.
• W3135154782 creator A5002249994 @default.
• W3135154782 creator A5007354108 @default.
• W3135154782 creator A5022134972 @default.
• W3135154782 creator A5037219867 @default.
• W3135154782 creator A5041746925 @default.
• W3135154782 creator A5079513514 @default.
• W3135154782 creator A5082501144 @default.
• W3135154782 date "2021-09-14" @default.
• W3135154782 modified "2023-09-26" @default.
• W3135154782 title "Transfection of STAT3 overexpression plasmid mediated through recombinant lentivirus promotes differentiation of bone marrow mesenchymal stem cells into neural cells in fetal rats with spina bifida aperta" @default.
• W3135154782 cites W1539435843 @default.
• W3135154782 cites W1965425054 @default.
• W3135154782 cites W1968245601 @default.
• W3135154782 cites W1996292266 @default.
• W3135154782 cites W2007569370 @default.
• W3135154782 cites W2008919101 @default.
• W3135154782 cites W2068038275 @default.
• W3135154782 cites W2094280126 @default.
• W3135154782 cites W2095425223 @default.
• W3135154782 cites W2111764891 @default.
• W3135154782 cites W2118976802 @default.
• W3135154782 cites W2188551989 @default.
• W3135154782 cites W2514135529 @default.
• W3135154782 cites W2587613447 @default.
• W3135154782 cites W2610328326 @default.
• W3135154782 cites W2741175738 @default.
• W3135154782 cites W2772429441 @default.
• W3135154782 cites W2892084880 @default.
• W3135154782 cites W2900590144 @default.
• W3135154782 cites W2904903270 @default.
• W3135154782 cites W2905217756 @default.
• W3135154782 cites W2905740418 @default.
• W3135154782 cites W2908401766 @default.
• W3135154782 cites W2947356196 @default.
• W3135154782 cites W2949795931 @default.
• W3135154782 cites W2954120469 @default.
• W3135154782 cites W2980477014 @default.
• W3135154782 cites W2991483425 @default.
• W3135154782 cites W3000361261 @default.
• W3135154782 cites W3006012565 @default.
• W3135154782 cites W3012190938 @default.
• W3135154782 cites W3013971777 @default.
• W3135154782 cites W3018338107 @default.
• W3135154782 cites W3020985128 @default.
• W3135154782 cites W3037405978 @default.
• W3135154782 doi "https://doi.org/10.18632/aging.203524" @default.
• W3135154782 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8457560" @default.
• W3135154782 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34520395" @default.
• W3135154782 hasPublicationYear "2021" @default.
• W3135154782 type Work @default.
• W3135154782 sameAs 3135154782 @default.
• W3135154782 citedByCount "4" @default.
• W3135154782 countsByYear W31351547822022 @default.
• W3135154782 countsByYear W31351547822023 @default.
• W3135154782 crossrefType "journal-article" @default.
• W3135154782 hasAuthorship W3135154782A5001208053 @default.
• W3135154782 hasAuthorship W3135154782A5001544145 @default.
• W3135154782 hasAuthorship W3135154782A5002249994 @default.
• W3135154782 hasAuthorship W3135154782A5007354108 @default.
• W3135154782 hasAuthorship W3135154782A5022134972 @default.
• W3135154782 hasAuthorship W3135154782A5037219867 @default.
• W3135154782 hasAuthorship W3135154782A5041746925 @default.
• W3135154782 hasAuthorship W3135154782A5079513514 @default.
• W3135154782 hasAuthorship W3135154782A5082501144 @default.
• W3135154782 hasBestOaLocation W31351547821 @default.
• W3135154782 hasConcept C104317684 @default.
• W3135154782 hasConcept C126322002 @default.
• W3135154782 hasConcept C136834591 @default.
• W3135154782 hasConcept C145103041 @default.
• W3135154782 hasConcept C153911025 @default.
• W3135154782 hasConcept C16685009 @default.
• W3135154782 hasConcept C190283241 @default.
• W3135154782 hasConcept C198826908 @default.
• W3135154782 hasConcept C2777738006 @default.
• W3135154782 hasConcept C2777933648 @default.
• W3135154782 hasConcept C2778923194 @default.
• W3135154782 hasConcept C28328180 @default.
• W3135154782 hasConcept C2911091166 @default.
• W3135154782 hasConcept C54009773 @default.
• W3135154782 hasConcept C54355233 @default.
• W3135154782 hasConcept C55493867 @default.
• W3135154782 hasConcept C71924100 @default.
• W3135154782 hasConcept C81885089 @default.
• W3135154782 hasConcept C86803240 @default.
• W3135154782 hasConcept C95444343 @default.
• W3135154782 hasConceptScore W3135154782C104317684 @default.
• W3135154782 hasConceptScore W3135154782C126322002 @default.
• W3135154782 hasConceptScore W3135154782C136834591 @default.
• W3135154782 hasConceptScore W3135154782C145103041 @default.
• W3135154782 hasConceptScore W3135154782C153911025 @default.
• W3135154782 hasConceptScore W3135154782C16685009 @default.
• W3135154782 hasConceptScore W3135154782C190283241 @default.
• W3135154782 hasConceptScore W3135154782C198826908 @default.
• W3135154782 hasConceptScore W3135154782C2777738006 @default.

• next