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- W3135155699 endingPage "3394" @default.
- W3135155699 startingPage "3386" @default.
- W3135155699 abstract "Neurodegenerative disorders (NDs) are a group of diseases that cause neural cell damage, leading to motility and/or cognitive dysfunctions. One of the causative agents is misfolded protein aggregates, which are considered as undruggable in terms of conventional tools, such as inhibitors and agonists/antagonists. Indeed, there is currently no FDA-approved drug for the causal treatment of NDs. However, emerging technologies for chemical protein degradation are opening up the possibility of selective elimination of target proteins through physiological protein degradation machineries, which do not depend on the functions of the target proteins. Here, we review recent efforts towards the treatment of NDs using chemical protein degradation technologies, and we briefly discuss the challenges and prospects." @default.
- W3135155699 created "2021-03-15" @default.
- W3135155699 creator A5040306907 @default.
- W3135155699 creator A5060338950 @default.
- W3135155699 date "2020-08-19" @default.
- W3135155699 modified "2023-09-24" @default.
- W3135155699 title "PROTACs and Other Chemical Protein Degradation Technologies for the Treatment of Neurodegenerative Disorders" @default.
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