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- W3135164509 abstract "Coenzyme A (CoA) is a well-known cofactor that plays an essential role in many metabolic reactions in all organisms. In Plasmodium falciparum , the most deadly among Plasmodium species that cause malaria, CoA and its biosynthetic pathway have been proven to be indispensable. The first and rate-limiting reaction in the CoA biosynthetic pathway is catalyzed by two putative pantothenate kinases ( Pf PanK1 and 2) in this parasite. Here we produced, purified, and biochemically characterized recombinant Pf PanK1 for the first time. Pf PanK1 showed activity using pantetheine besides pantothenate, as the primary substrate, indicating that CoA biosynthesis in the blood stage of P. falciparum can bypass pantothenate. We further developed a robust and reliable screening system to identify inhibitors using recombinant Pf PanK1 and identified four Pf PanK inhibitors from natural compounds." @default.
- W3135164509 created "2021-03-15" @default.
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- W3135164509 date "2021-03-09" @default.
- W3135164509 modified "2023-10-16" @default.
- W3135164509 title "Characterization of Plasmodium falciparum Pantothenate Kinase and Identification of Its Inhibitors From Natural Products" @default.
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- W3135164509 doi "https://doi.org/10.3389/fcimb.2021.639065" @default.
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