FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3135171635> ?p ?o ?g. }

• W3135171635 endingPage "1957" @default.
• W3135171635 startingPage "1943" @default.
• W3135171635 abstract "Abstract Neuroimaging genomic studies of autism spectrum disorder and schizophrenia have mainly adopted a ‘top-down’ approach, beginning with the behavioural diagnosis, and moving down to intermediate brain phenotypes and underlying genetic factors. Advances in imaging and genomics have been successfully applied to increasingly large case-control studies. As opposed to diagnostic-first approaches, the bottom-up strategy begins at the level of molecular factors enabling the study of mechanisms related to biological risk, irrespective of diagnoses or clinical manifestations. The latter strategy has emerged from questions raised by top-down studies: why are mutations and brain phenotypes over-represented in individuals with a psychiatric diagnosis? Are they related to core symptoms of the disease or to comorbidities? Why are mutations and brain phenotypes associated with several psychiatric diagnoses? Do they impact a single dimension contributing to all diagnoses? In this review, we aimed at summarizing imaging genomic findings in autism and schizophrenia as well as neuropsychiatric variants associated with these conditions. Top-down studies of autism and schizophrenia identified patterns of neuroimaging alterations with small effect-sizes and an extreme polygenic architecture. Genomic variants and neuroimaging patterns are shared across diagnostic categories suggesting pleiotropic mechanisms at the molecular and brain network levels. Although the field is gaining traction; characterizing increasingly reproducible results, it is unlikely that top-down approaches alone will be able to disentangle mechanisms involved in autism or schizophrenia. In stark contrast with top-down approaches, bottom-up studies showed that the effect-sizes of high-risk neuropsychiatric mutations are equally large for neuroimaging and behavioural traits. Low specificity has been perplexing with studies showing that broad classes of genomic variants affect a similar range of behavioural and cognitive dimensions, which may be consistent with the highly polygenic architecture of psychiatric conditions. The surprisingly discordant effect sizes observed between genetic and diagnostic first approaches underscore the necessity to decompose the heterogeneity hindering case-control studies in idiopathic conditions. We propose a systematic investigation across a broad spectrum of neuropsychiatric variants to identify putative latent dimensions underlying idiopathic conditions. Gene expression data on temporal, spatial and cell type organization in the brain have also considerable potential for parsing the mechanisms contributing to these dimensions’ phenotypes. While large neuroimaging genomic datasets are now available in unselected populations, there is an urgent need for data on individuals with a range of psychiatric symptoms and high-risk genomic variants. Such efforts together with more standardized methods will improve mechanistically informed predictive modelling for diagnosis and clinical outcomes." @default.
• W3135171635 created "2021-03-15" @default.
• W3135171635 creator A5003523497 @default.
• W3135171635 creator A5009114084 @default.
• W3135171635 creator A5016285763 @default.
• W3135171635 creator A5029037826 @default.
• W3135171635 creator A5059250686 @default.
• W3135171635 creator A5076029433 @default.
• W3135171635 date "2021-03-11" @default.
• W3135171635 modified "2023-10-16" @default.
• W3135171635 title "Dissecting autism and schizophrenia through neuroimaging genomics" @default.
• W3135171635 cites W1876943069 @default.
• W3135171635 cites W1965210252 @default.
• W3135171635 cites W1971646616 @default.
• W3135171635 cites W1977465442 @default.
• W3135171635 cites W1977796124 @default.
• W3135171635 cites W1979085032 @default.
• W3135171635 cites W1981693548 @default.
• W3135171635 cites W1983660707 @default.
• W3135171635 cites W1986094520 @default.
• W3135171635 cites W1987942611 @default.
• W3135171635 cites W1988903920 @default.
• W3135171635 cites W1991633140 @default.
• W3135171635 cites W1996124672 @default.
• W3135171635 cites W2000010950 @default.
• W3135171635 cites W2001233655 @default.
• W3135171635 cites W2001477615 @default.
• W3135171635 cites W2012342294 @default.
• W3135171635 cites W2016423032 @default.
• W3135171635 cites W2023962370 @default.
• W3135171635 cites W2024317089 @default.
• W3135171635 cites W2025159391 @default.
• W3135171635 cites W2025551837 @default.
• W3135171635 cites W2032745668 @default.
• W3135171635 cites W2033021653 @default.
• W3135171635 cites W2040052684 @default.
• W3135171635 cites W2045227722 @default.
• W3135171635 cites W2050161506 @default.
• W3135171635 cites W2053904865 @default.
• W3135171635 cites W2058684270 @default.
• W3135171635 cites W2080984518 @default.
• W3135171635 cites W2082704080 @default.
• W3135171635 cites W2085198610 @default.
• W3135171635 cites W2086039500 @default.
• W3135171635 cites W2088786313 @default.
• W3135171635 cites W2098924721 @default.
• W3135171635 cites W2102521965 @default.
• W3135171635 cites W2109214922 @default.
• W3135171635 cites W2117381227 @default.
• W3135171635 cites W2119195417 @default.
• W3135171635 cites W2127070446 @default.
• W3135171635 cites W2129867386 @default.
• W3135171635 cites W2131104106 @default.
• W3135171635 cites W2139505744 @default.
• W3135171635 cites W2139870060 @default.
• W3135171635 cites W2141704631 @default.
• W3135171635 cites W2144556506 @default.
• W3135171635 cites W2145680887 @default.
• W3135171635 cites W2149959145 @default.
• W3135171635 cites W2154432610 @default.
• W3135171635 cites W2155347288 @default.
• W3135171635 cites W2155624710 @default.
• W3135171635 cites W2156691676 @default.
• W3135171635 cites W2161641617 @default.
• W3135171635 cites W2167868121 @default.
• W3135171635 cites W2171777347 @default.
• W3135171635 cites W2175782740 @default.
• W3135171635 cites W2184230181 @default.
• W3135171635 cites W2188836807 @default.
• W3135171635 cites W2202453598 @default.
• W3135171635 cites W2256016639 @default.
• W3135171635 cites W2260830658 @default.
• W3135171635 cites W2277462866 @default.
• W3135171635 cites W2285309825 @default.
• W3135171635 cites W2337092408 @default.
• W3135171635 cites W2340656051 @default.
• W3135171635 cites W241009001 @default.
• W3135171635 cites W2497939844 @default.
• W3135171635 cites W2507387536 @default.
• W3135171635 cites W2507392736 @default.
• W3135171635 cites W2522924024 @default.
• W3135171635 cites W2536956629 @default.
• W3135171635 cites W2548021123 @default.
• W3135171635 cites W2551102722 @default.
• W3135171635 cites W2557111525 @default.
• W3135171635 cites W2562365749 @default.
• W3135171635 cites W2569108694 @default.
• W3135171635 cites W2586872334 @default.
• W3135171635 cites W2593371527 @default.
• W3135171635 cites W2593658800 @default.
• W3135171635 cites W2604697269 @default.
• W3135171635 cites W2609984900 @default.
• W3135171635 cites W2610263234 @default.
• W3135171635 cites W2614349964 @default.
• W3135171635 cites W2617908176 @default.
• W3135171635 cites W2625516444 @default.
• W3135171635 cites W2741837533 @default.
• W3135171635 cites W2751739125 @default.

• next