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- W3135187804 abstract "Abstract Granulosa cells (GCs) play important roles in the regulation of ovarian functions, and in vitro culture is a relevant model for the study of steroidogenesis in ovarian follicles. Thus, growth factors secreted by the oocyte, like Growth and Differentiation Factor 9 (GDF9) and Bone Morphogenetic Protein 15 (BMP15), play an important part in the luteinization of granulosa cells. The aim of this work was to express GDF9 and BMP15 genes in bovine GCs in vitro and evaluate their effects on the luteinization process. Samples of culture medium and GCs transfected with GDF9 and BMP15 were obtained for 21 consecutive days to analyse the steroidogenic hormones' concentration (progesterone (P 4 ) and estradiol (E 2 )) and the expression of STAR, GDF9 and BMP15 and their respective receptors. The results demonstrated an inhibitory effect of GDF9 and BMPF15 on P 4 secretion in bovine GCs cultured in vitro. Moreover, our study demonstrated the entire expression of their respective receptors (TGFBR1, BMPR1B and BMPR2) and the inhibition of the steroidogenic marker, STAR gene. This work sheds light on a novel biological function of BMP15 and GDF9 in bovine GCs physiology, which could elucidate a non‐described biological role for GDF9 and BMP15 in bovine granulosa cells' metabolism." @default.
- W3135187804 created "2021-03-15" @default.
- W3135187804 creator A5033167034 @default.
- W3135187804 creator A5074688555 @default.
- W3135187804 date "2021-03-22" @default.
- W3135187804 modified "2023-10-17" @default.
- W3135187804 title "Effects of Growth and Differentiation Factor 9 and Bone Morphogenetic Protein 15 overexpression on the steroidogenic metabolism in bovine granulosa cells in vitro" @default.
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- W3135187804 doi "https://doi.org/10.1111/rda.13923" @default.
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- W3135187804 hasPublicationYear "2021" @default.
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