FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3135194645> ?p ?o ?g. }

• W3135194645 abstract "Background: Distinction of IDH mutant and wildtype GBMs is challenging on MRI, since conventional imaging shows considerable overlap. While few studies employed deep-learning in a mixed low/high grade glioma population, a GBM-specific model is still lacking in the literature. Our objective was to develop a deep-learning model for IDH prediction in GBM by using Convoluted Neural Networks (CNN) on multiparametric MRI. Methods: We included 100 adult patients with pathologically proven GBM and IDH testing. MRI data included: morphologic sequences, rCBV and ADC maps. Tumor area was obtained by a bounding box function on the axial slice with widest tumor extension on T2 images and was projected on every sequence. Data was split into training and test (80:20) sets. A 4 block 2D - CNN architecture was implemented for IDH prediction on every MRI sequence. IDH mutation probability was calculated with softmax activation function from the last dense layer. Highest performance was calculated accounting for model accuracy and categorical cross-entropy loss (CCEL) in the test cohort. Results: Our model achieved the following performance: T1 (accuracy 77%, CCEL 1.4), T2 (accuracy 67%, CCEL 2.41), FLAIR (accuracy 77%, CCEL 1.98), MPRAGE (accuracy 66%, CCEL 2.55), rCBV (accuracy 83%, CCEL 0.64). ADC achieved lower performance. Conclusion: We built a GBM-tailored deep-learning model for IDH mutation prediction, achieving accuracy of 83% with rCBV maps. High predictivity of perfusion images may reflect the known correlation between IDH, hypoxia inducible factor (HIF) and neoangiogenesis. This model may set a path for non-invasive evaluation of IDH mutation in GBM." @default.
• W3135194645 created "2021-03-15" @default.
• W3135194645 creator A5005529168 @default.
• W3135194645 creator A5013077936 @default.
• W3135194645 creator A5016478683 @default.
• W3135194645 creator A5016965442 @default.
• W3135194645 creator A5018740016 @default.
• W3135194645 creator A5039453666 @default.
• W3135194645 creator A5053124870 @default.
• W3135194645 creator A5055126952 @default.
• W3135194645 creator A5061161385 @default.
• W3135194645 creator A5071062410 @default.
• W3135194645 creator A5073262191 @default.
• W3135194645 creator A5074399091 @default.
• W3135194645 creator A5080358987 @default.
• W3135194645 date "2021-02-24" @default.
• W3135194645 modified "2023-10-15" @default.
• W3135194645 title "Deep learning can differentiate IDH-mutant from IDH-wild type GBM" @default.
• W3135194645 cites W1408981388 @default.
• W3135194645 cites W1717181322 @default.
• W3135194645 cites W1865428194 @default.
• W3135194645 cites W1996908572 @default.
• W3135194645 cites W2020788438 @default.
• W3135194645 cites W2047232697 @default.
• W3135194645 cites W2047267920 @default.
• W3135194645 cites W2055867081 @default.
• W3135194645 cites W2068397652 @default.
• W3135194645 cites W2080452140 @default.
• W3135194645 cites W2105348749 @default.
• W3135194645 cites W2106455035 @default.
• W3135194645 cites W2126817554 @default.
• W3135194645 cites W2131360477 @default.
• W3135194645 cites W2143568469 @default.
• W3135194645 cites W2154313451 @default.
• W3135194645 cites W2161648951 @default.
• W3135194645 cites W2297267460 @default.
• W3135194645 cites W2309914605 @default.
• W3135194645 cites W2337069966 @default.
• W3135194645 cites W2460918282 @default.
• W3135194645 cites W2566749675 @default.
• W3135194645 cites W2611746820 @default.
• W3135194645 cites W2732357513 @default.
• W3135194645 cites W2739357331 @default.
• W3135194645 cites W2757935580 @default.
• W3135194645 cites W2760969998 @default.
• W3135194645 cites W2763211814 @default.
• W3135194645 cites W2769012178 @default.
• W3135194645 cites W2770261599 @default.
• W3135194645 cites W2801007594 @default.
• W3135194645 cites W2802159733 @default.
• W3135194645 cites W2883420106 @default.
• W3135194645 cites W2904997892 @default.
• W3135194645 cites W2912884588 @default.
• W3135194645 cites W2949513994 @default.
• W3135194645 cites W2953298857 @default.
• W3135194645 cites W2954996726 @default.
• W3135194645 cites W2970202650 @default.
• W3135194645 cites W2980444100 @default.
• W3135194645 cites W3007230112 @default.
• W3135194645 cites W3014970872 @default.
• W3135194645 cites W3015988344 @default.
• W3135194645 hasPublicationYear "2021" @default.
• W3135194645 type Work @default.
• W3135194645 sameAs 3135194645 @default.
• W3135194645 citedByCount "0" @default.
• W3135194645 crossrefType "posted-content" @default.
• W3135194645 hasAuthorship W3135194645A5005529168 @default.
• W3135194645 hasAuthorship W3135194645A5013077936 @default.
• W3135194645 hasAuthorship W3135194645A5016478683 @default.
• W3135194645 hasAuthorship W3135194645A5016965442 @default.
• W3135194645 hasAuthorship W3135194645A5018740016 @default.
• W3135194645 hasAuthorship W3135194645A5039453666 @default.
• W3135194645 hasAuthorship W3135194645A5053124870 @default.
• W3135194645 hasAuthorship W3135194645A5055126952 @default.
• W3135194645 hasAuthorship W3135194645A5061161385 @default.
• W3135194645 hasAuthorship W3135194645A5071062410 @default.
• W3135194645 hasAuthorship W3135194645A5073262191 @default.
• W3135194645 hasAuthorship W3135194645A5074399091 @default.
• W3135194645 hasAuthorship W3135194645A5080358987 @default.
• W3135194645 hasConcept C101070640 @default.
• W3135194645 hasConcept C108583219 @default.
• W3135194645 hasConcept C126838900 @default.
• W3135194645 hasConcept C143409427 @default.
• W3135194645 hasConcept C153180895 @default.
• W3135194645 hasConcept C154945302 @default.
• W3135194645 hasConcept C188441871 @default.
• W3135194645 hasConcept C2776194525 @default.
• W3135194645 hasConcept C2908647359 @default.
• W3135194645 hasConcept C2989005 @default.
• W3135194645 hasConcept C41008148 @default.
• W3135194645 hasConcept C502942594 @default.
• W3135194645 hasConcept C71924100 @default.
• W3135194645 hasConcept C99454951 @default.
• W3135194645 hasConceptScore W3135194645C101070640 @default.
• W3135194645 hasConceptScore W3135194645C108583219 @default.
• W3135194645 hasConceptScore W3135194645C126838900 @default.
• W3135194645 hasConceptScore W3135194645C143409427 @default.
• W3135194645 hasConceptScore W3135194645C153180895 @default.
• W3135194645 hasConceptScore W3135194645C154945302 @default.
• W3135194645 hasConceptScore W3135194645C188441871 @default.

• next