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- W3135215508 endingPage "184" @default.
- W3135215508 startingPage "184" @default.
- W3135215508 abstract "Sudden infant death syndrome (SIDS) is defined as “the sudden death of an infant under 1 year of age which remains unexplained after thorough investigation including a complete autopsy, death scene investigation, and detailed clinical and pathological review”. A significant decrease of SIDS deaths occurred in the last decades in most countries after the beginning of national campaigns, mainly as a consequence of the implementation of risk reduction action mostly concentrating on the improvement of sleep conditions. Nevertheless, infant mortality from SIDS still remains unacceptably high. There is an urgent need to get insight into previously unexplored aspects of the brain system with a special focus on high-risk groups. SIDS pathogenesis is associated with a multifactorial condition that comprehends genetic, environmental and sociocultural factors. Effective prevention of SIDS requires multiple interventions from different fields. Developing brain susceptibility, intrinsic vulnerability and early identification of infants with high risk of SIDS represents a challenge. Progress in SIDS research appears to be fundamental to the ultimate aim of eradicating SIDS deaths. A complex model that combines different risk factor data from biomarkers and omic analysis may represent a tool to identify a SIDS risk profile in newborn settings. If high risk is detected, the infant may be referred for further investigations and follow ups. This review aims to illustrate the most recent discoveries from different fields, analyzing the neuroanatomical, genetic, metabolic, proteomic, environmental and sociocultural aspects related to SIDS." @default.
- W3135215508 created "2021-03-15" @default.
- W3135215508 creator A5002525725 @default.
- W3135215508 creator A5009727581 @default.
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- W3135215508 creator A5080263193 @default.
- W3135215508 creator A5082965767 @default.
- W3135215508 date "2021-02-26" @default.
- W3135215508 modified "2023-09-27" @default.
- W3135215508 title "Sudden Infant Death Syndrome: Beyond Risk Factors" @default.
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