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• W3135217967 abstract "The auditory and vestibular organs of the inner ear and the neurons that innervate them originate from Sox2-positive and Notch-active neurosensory domains specified at early stages of otic development. Sox2 is initially present throughout the otic placode and otocyst, and then it becomes progressively restricted to a ventro-medial domain. Using gain- and loss-of-function approaches in the chicken otocyst, we show that these early changes in Sox2 expression are regulated in a dose-dependent manner by Wnt/beta-catenin signalling. Both high and very low levels of Wnt activity repress Sox2 and neurosensory competence. However, intermediate levels allow the maintenance of Sox2 expression and sensory organ formation. We propose that a dorso-ventral (high-to-low) gradient and wave of Wnt activity initiated at the dorsal rim of the otic placode progressively restricts Sox2 and Notch activity to the ventral half of the otocyst, thereby positioning the neurosensory competent domains in the inner ear." @default.
• W3135217967 created "2021-03-15" @default.
• W3135217967 creator A5039371901 @default.
• W3135217967 creator A5059696993 @default.
• W3135217967 date "2021-03-11" @default.
• W3135217967 modified "2023-10-18" @default.
• W3135217967 title "A gradient of Wnt activity positions the neurosensory domains of the inner ear" @default.
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• W3135217967 doi "https://doi.org/10.7554/elife.59540" @default.
• W3135217967 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7993990" @default.
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• W3135217967 hasPublicationYear "2021" @default.
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