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- W3135236090 endingPage "279" @default.
- W3135236090 startingPage "279" @default.
- W3135236090 abstract "Since December 2019, the SARS-CoV-2 (COVID-19) pandemic has transfixed the medical world. COVID-19 symptoms vary from mild to severe and underlying chronic conditions such as pulmonary/cardiovascular disease and diabetes induce excessive inflammatory responses to COVID-19 and these underlying chronic diseases are mediated by endothelial dysfunction. Acute respiratory distress syndrome (ARDS) is the most common cause of death in COVID-19 patients, but coagulation induced by excessive inflammation, thrombosis, and disseminated intravascular coagulation (DIC) also induce death by multiple-organ dysfunction syndrome. These associations imply that maintaining endothelial integrity is crucial for favorable prognoses with COVID-19 and therapeutic intervention to support this may be beneficial. Here, we summarize the extent of heart injuries, ischemic stroke and hemorrhage, acute kidney injury, and liver injury caused by immune-mediated endothelial dysfunction that result in the phenomenon of multi-organ dysfunction seen in COVID-19 patients. Moreover, the potential therapeutic effect of angiotensin receptor blockers and angiotensin-converting enzyme inhibitors that improve endothelial dysfunction as well as the bradykinin storm are discussed." @default.
- W3135236090 created "2021-03-15" @default.
- W3135236090 creator A5003766009 @default.
- W3135236090 creator A5042897629 @default.
- W3135236090 creator A5067111837 @default.
- W3135236090 creator A5075566852 @default.
- W3135236090 creator A5081171404 @default.
- W3135236090 creator A5089076259 @default.
- W3135236090 date "2021-03-10" @default.
- W3135236090 modified "2023-09-24" @default.
- W3135236090 title "Severe COVID-19 Infection Associated with Endothelial Dysfunction Induces Multiple Organ Dysfunction: A Review of Therapeutic Interventions" @default.
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