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- W3135277514 abstract "Accurate mapping of gastrointestinal stromal tumors (GIST) during surgery is difficult, which contributes to the suboptimal diagnosis and recurrence of cancers. To overcome this limitation, we developed a near-infrared (NIR) fluorescent nanoprobe for real-time navigation of GIST using a targeted strategy against the CD117 ligand stem cell factor (SCF). A zwitterionic NIR fluorophore conjugated to SCF showed specific binding to a xenograft mouse model of CD117-positive GIST-T1 with minimal nonspecific tissue signals. This promising intraoperative imaging strategy could be further explored for early diagnosis and follow-up of GIST prognosis before and after surgical resection." @default.
- W3135277514 created "2021-03-15" @default.
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- W3135277514 date "2021-03-05" @default.
- W3135277514 modified "2023-09-24" @default.
- W3135277514 title "CD117-targeted intraoperative imaging of gastrointestinal stromal tumor using zwitterionic near-infrared fluorophores" @default.
- W3135277514 doi "https://doi.org/10.1117/12.2578416" @default.
- W3135277514 hasPublicationYear "2021" @default.
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