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• W3135283094 endingPage "103284" @default.
• W3135283094 startingPage "103284" @default.
• W3135283094 abstract "A systematic review (SR) and meta-analysis were conducted to determine the prevalence of PI3K-AKT-mTOR signaling pathway mutations in patients with head and neck cancer (HNC). Overall, 105 studies comprising 8630 patients and 1306 mutations were selected. The estimated mutations prevalence was 13 % for PIK3CA (95 % confidence interval [CI] = 11–14; I2 = 82 %; p < 0.0001), 4% for PTEN (95 % CI = 3–5; I2 = 55 %; p < 0.0001), 3% for MTOR (95 % CI = 2–4; I2 = 5%; p = 0.40), and 2% for AKT (95 % CI = 1–2; I2 = 50 %; p = 0.0001). We further stratified the available data of the participants according to risk factors and tumor characteristics, including HPV infection, tobacco use, alcohol exposure, TNM stage, and histological tumor differentiation, and performed subgroup analysis. We identified significant associations between PI3K-AKT-mTOR pathway-associated mutations and advanced TNM stage (odds ratio [OR] = 0.20; 95 % CI = 0.09–0.44; I² = 71 %; p = 0.0001) and oropharyngeal HPV-positive tumors and PIK3CA mutations (OR = 17.48; 95 % CI = 4.20–72.76; I² = 69 %; p < 0.0002). No associations were found between alcohol and tobacco exposure, and tumor differentiation grade. This SR demonstrated that the PI3K-AKT-mTOR pathway emerges as a potential prognostic factor and could offer a molecular basis for future studies on therapeutic targeting in HNC patients." @default.
• W3135283094 created "2021-03-15" @default.
• W3135283094 creator A5000140098 @default.
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• W3135283094 date "2021-04-01" @default.
• W3135283094 modified "2023-10-09" @default.
• W3135283094 title "Worldwide prevalence of PI3K-AKT-mTOR pathway mutations in head and neck cancer: A systematic review and meta-analysis" @default.
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