FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3135297157> ?p ?o ?g. }

• W3135297157 abstract "There is no consensus on the effect of recombinant human GH (rhGH) therapy on skeletal maturation in children despite the current practice of annual monitoring of skeletal maturation with bone age in children on rhGH therapy.To investigate the effects of long-term rhGH therapy on skeletal age in children and explore the accuracy of bone age-predicted adult height (BAPAH) at different ages based on 13 years of longitudinal data.A retrospective longitudinal study of 71 subjects aged 2 to 16 years, mean 9.9 ± 3.8 years, treated with rhGH for nonsyndromic short stature for a duration of 2 to 14 years, mean, 5.5 ± 2.6 years. Subjects with syndromic short stature and systemic illnesses such as renal failure were excluded.Bone age minus chronological age (BA-CA) did not differ significantly between baseline and the end of rhGH therapy (-1.05 ± 1.42 vs -0.69 ± 1.63, P = 0.09). Piecewise regression, however, showed a quantifiable catch-up phenomenon in BA of 1.5 months per year of rhGH therapy in the first 6.5 years (P = 0.017) that plateaued thereafter (P = 0.88). BAPAH overestimated near-adult height in younger subjects but became more accurate in older subjects (P < 0.0001). IGF-I levels correlated significantly with increases in child's height and BA-CA.Long-term rhGH therapy demonstrated an initial catch-up phenomenon in skeletal maturation in the first 6.5 years that plateaued thereafter with no overall significant advancement in bone age. These findings are reassuring and support strategic, but not the insurance company mandated reflexive annual monitoring of skeletal maturation with bone age in children receiving rhGH therapy." @default.
• W3135297157 created "2021-03-15" @default.
• W3135297157 creator A5022367276 @default.
• W3135297157 creator A5028139163 @default.
• W3135297157 creator A5043437032 @default.
• W3135297157 creator A5049812521 @default.
• W3135297157 creator A5053924893 @default.
• W3135297157 creator A5060300296 @default.
• W3135297157 date "2021-03-05" @default.
• W3135297157 modified "2023-10-01" @default.
• W3135297157 title "Long-term GH Therapy Does Not Advance Skeletal Maturation in Children and Adolescents" @default.
• W3135297157 cites W1494268162 @default.
• W3135297157 cites W1957195117 @default.
• W3135297157 cites W1965561480 @default.
• W3135297157 cites W1966027511 @default.
• W3135297157 cites W1967692519 @default.
• W3135297157 cites W1975656299 @default.
• W3135297157 cites W1986607163 @default.
• W3135297157 cites W2001255616 @default.
• W3135297157 cites W2008855400 @default.
• W3135297157 cites W2013021484 @default.
• W3135297157 cites W2023742446 @default.
• W3135297157 cites W2032020304 @default.
• W3135297157 cites W2032159547 @default.
• W3135297157 cites W2045531402 @default.
• W3135297157 cites W2048370865 @default.
• W3135297157 cites W2053105417 @default.
• W3135297157 cites W2054433727 @default.
• W3135297157 cites W2062498533 @default.
• W3135297157 cites W2070640693 @default.
• W3135297157 cites W2076104915 @default.
• W3135297157 cites W2100706982 @default.
• W3135297157 cites W2128962458 @default.
• W3135297157 cites W2131233882 @default.
• W3135297157 cites W2163987680 @default.
• W3135297157 cites W2165296600 @default.
• W3135297157 cites W2171589158 @default.
• W3135297157 cites W2233041445 @default.
• W3135297157 cites W2312070181 @default.
• W3135297157 cites W2546962386 @default.
• W3135297157 cites W2592087460 @default.
• W3135297157 cites W2611081548 @default.
• W3135297157 cites W2742144579 @default.
• W3135297157 cites W2794868630 @default.
• W3135297157 cites W2796398079 @default.
• W3135297157 cites W2928958470 @default.
• W3135297157 cites W2973019498 @default.
• W3135297157 cites W57320245 @default.
• W3135297157 cites W967393384 @default.
• W3135297157 cites W1982987309 @default.
• W3135297157 doi "https://doi.org/10.1210/jendso/bvab036" @default.
• W3135297157 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8035984" @default.
• W3135297157 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33860132" @default.
• W3135297157 hasPublicationYear "2021" @default.
• W3135297157 type Work @default.
• W3135297157 sameAs 3135297157 @default.
• W3135297157 citedByCount "2" @default.
• W3135297157 countsByYear W31352971572021 @default.
• W3135297157 countsByYear W31352971572022 @default.
• W3135297157 crossrefType "journal-article" @default.
• W3135297157 hasAuthorship W3135297157A5022367276 @default.
• W3135297157 hasAuthorship W3135297157A5028139163 @default.
• W3135297157 hasAuthorship W3135297157A5043437032 @default.
• W3135297157 hasAuthorship W3135297157A5049812521 @default.
• W3135297157 hasAuthorship W3135297157A5053924893 @default.
• W3135297157 hasAuthorship W3135297157A5060300296 @default.
• W3135297157 hasBestOaLocation W31352971571 @default.
• W3135297157 hasConcept C126322002 @default.
• W3135297157 hasConcept C134018914 @default.
• W3135297157 hasConcept C187212893 @default.
• W3135297157 hasConcept C2777871287 @default.
• W3135297157 hasConcept C71924100 @default.
• W3135297157 hasConcept C89551170 @default.
• W3135297157 hasConceptScore W3135297157C126322002 @default.
• W3135297157 hasConceptScore W3135297157C134018914 @default.
• W3135297157 hasConceptScore W3135297157C187212893 @default.
• W3135297157 hasConceptScore W3135297157C2777871287 @default.
• W3135297157 hasConceptScore W3135297157C71924100 @default.
• W3135297157 hasConceptScore W3135297157C89551170 @default.
• W3135297157 hasIssue "5" @default.
• W3135297157 hasLocation W31352971571 @default.
• W3135297157 hasLocation W31352971572 @default.
• W3135297157 hasLocation W31352971573 @default.
• W3135297157 hasLocation W31352971574 @default.
• W3135297157 hasLocation W31352971575 @default.
• W3135297157 hasOpenAccess W3135297157 @default.
• W3135297157 hasPrimaryLocation W31352971571 @default.
• W3135297157 hasRelatedWork W1985732893 @default.
• W3135297157 hasRelatedWork W2009766761 @default.
• W3135297157 hasRelatedWork W2016753588 @default.
• W3135297157 hasRelatedWork W2030010168 @default.
• W3135297157 hasRelatedWork W2048955825 @default.
• W3135297157 hasRelatedWork W2105710561 @default.
• W3135297157 hasRelatedWork W2117992582 @default.
• W3135297157 hasRelatedWork W2157645473 @default.
• W3135297157 hasRelatedWork W2164588706 @default.
• W3135297157 hasRelatedWork W4243440205 @default.
• W3135297157 hasVolume "5" @default.
• W3135297157 isParatext "false" @default.
• W3135297157 isRetracted "false" @default.

• next