Matches in SemOpenAlex for { <https://semopenalex.org/work/W3135306523> ?p ?o ?g. }
- W3135306523 endingPage "28" @default.
- W3135306523 startingPage "20" @default.
- W3135306523 abstract "Fungal infections have predominantly increased worldwide that leads to morbidity and mortality in severe cases. Invasive candidiasis and other pathogenic fungal infections are a major problem in immunocompromised individuals and post-operative patients. Increasing resistance to existing antifungal drugs calls for the identification of novel antifungal drug targets for chemotherapeutic interventions. This demand for identification and characterization of novel drug targets leads to the development of effective antifungal therapy against drug resistant fungi. Heat shock proteins (HSPs) are important for various biological processes like protein folding, posttranslational modifications, transcription, translation, and protein aggregation. HSPs are involved in maintaining homeostasis of the cell. A subgroup of HSPs is small heat shock proteins (sHSPs), which functions as cellular chaperones. They are having a significant role in the many cellular functions like development, cytoskeletal organization, apoptosis, membrane lipid polymorphism, differentiation, autophagy, in infection recognition and are major players in various stresses like osmotic stress, pH stress, etc. Studies have shown that fungal cells express increased levels of sHSPs upon antifungal drug induced stress responses. Here we review the important role of small heat shock proteins (sHSPs) in fungal diseases and their potential as antifungal targets." @default.
- W3135306523 created "2021-03-15" @default.
- W3135306523 creator A5051274272 @default.
- W3135306523 date "2021-02-27" @default.
- W3135306523 modified "2023-09-24" @default.
- W3135306523 title "Exploring Small Heat Shock Proteins (sHSPs) for Targeting Drug Resistance in Candida albicans and other Pathogenic Fungi" @default.
- W3135306523 cites W1508344064 @default.
- W3135306523 cites W1535859471 @default.
- W3135306523 cites W1537274817 @default.
- W3135306523 cites W1592352228 @default.
- W3135306523 cites W1760120130 @default.
- W3135306523 cites W1961089940 @default.
- W3135306523 cites W1967172808 @default.
- W3135306523 cites W1968023849 @default.
- W3135306523 cites W1978290724 @default.
- W3135306523 cites W1978684735 @default.
- W3135306523 cites W1980881069 @default.
- W3135306523 cites W1981191309 @default.
- W3135306523 cites W1985532753 @default.
- W3135306523 cites W1995380559 @default.
- W3135306523 cites W2004503571 @default.
- W3135306523 cites W2011629853 @default.
- W3135306523 cites W2012279651 @default.
- W3135306523 cites W2014496529 @default.
- W3135306523 cites W2025493128 @default.
- W3135306523 cites W2028371003 @default.
- W3135306523 cites W2032625890 @default.
- W3135306523 cites W2034700901 @default.
- W3135306523 cites W2041059150 @default.
- W3135306523 cites W2048141156 @default.
- W3135306523 cites W2054063955 @default.
- W3135306523 cites W2059277971 @default.
- W3135306523 cites W2059620312 @default.
- W3135306523 cites W2066050324 @default.
- W3135306523 cites W2068262186 @default.
- W3135306523 cites W2068328991 @default.
- W3135306523 cites W2068928962 @default.
- W3135306523 cites W2069299972 @default.
- W3135306523 cites W2070051434 @default.
- W3135306523 cites W2070499437 @default.
- W3135306523 cites W2075467836 @default.
- W3135306523 cites W2081581252 @default.
- W3135306523 cites W2082444310 @default.
- W3135306523 cites W2090227081 @default.
- W3135306523 cites W2091902964 @default.
- W3135306523 cites W2093997770 @default.
- W3135306523 cites W2099421513 @default.
- W3135306523 cites W2100752201 @default.
- W3135306523 cites W2101457798 @default.
- W3135306523 cites W2104880204 @default.
- W3135306523 cites W2106202218 @default.
- W3135306523 cites W2110874942 @default.
- W3135306523 cites W2114914917 @default.
- W3135306523 cites W2115172705 @default.
- W3135306523 cites W2116980830 @default.
- W3135306523 cites W2117823077 @default.
- W3135306523 cites W2119647378 @default.
- W3135306523 cites W2122436557 @default.
- W3135306523 cites W2126700110 @default.
- W3135306523 cites W2128037926 @default.
- W3135306523 cites W2128511484 @default.
- W3135306523 cites W2135471957 @default.
- W3135306523 cites W2136677555 @default.
- W3135306523 cites W2138367289 @default.
- W3135306523 cites W2140905627 @default.
- W3135306523 cites W2141612833 @default.
- W3135306523 cites W2142554739 @default.
- W3135306523 cites W2143227193 @default.
- W3135306523 cites W2146225432 @default.
- W3135306523 cites W2153104382 @default.
- W3135306523 cites W2156992532 @default.
- W3135306523 cites W2157725957 @default.
- W3135306523 cites W2162821262 @default.
- W3135306523 cites W2164060511 @default.
- W3135306523 cites W2165113979 @default.
- W3135306523 cites W2167502710 @default.
- W3135306523 cites W2171023563 @default.
- W3135306523 cites W2227223477 @default.
- W3135306523 cites W2742305482 @default.
- W3135306523 cites W2750793165 @default.
- W3135306523 cites W2804800648 @default.
- W3135306523 cites W2891684978 @default.
- W3135306523 doi "https://doi.org/10.22207/jpam.15.1.42" @default.
- W3135306523 hasPublicationYear "2021" @default.
- W3135306523 type Work @default.
- W3135306523 sameAs 3135306523 @default.
- W3135306523 citedByCount "1" @default.
- W3135306523 countsByYear W31353065232023 @default.
- W3135306523 crossrefType "journal-article" @default.
- W3135306523 hasAuthorship W3135306523A5051274272 @default.
- W3135306523 hasBestOaLocation W31353065231 @default.
- W3135306523 hasConcept C104317684 @default.
- W3135306523 hasConcept C114851261 @default.
- W3135306523 hasConcept C137984847 @default.
- W3135306523 hasConcept C146621620 @default.
- W3135306523 hasConcept C168529131 @default.
- W3135306523 hasConcept C190283241 @default.
- W3135306523 hasConcept C203522944 @default.