FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3135317966> ?p ?o ?g. }

• W3135317966 abstract "Abstract Objectives This study aimed to investigate the protective effect of SCARF1 on acute rejection (AR), phagocytic clearance of Kupffer cells (KCs), M2 polarization and the exact mechanism underlying these processes. Methods AAV was transfected into the portal vein of rats, and AR and immune tolerance (IT) models of liver transplantation were established. Liver tissue and blood samples were collected. The level of SCARF1 was detected via WB and immunohistochemical staining. Pathological changes in liver tissue were detected using HE staining. Apoptotic cells were detected using TUNEL staining. KC polarization was assessed via immunohistochemical staining. Primary KCs were isolated and co‐cultured with apoptotic T lymphocytes. Phagocytosis of apoptotic cells and polarization of KCs were both detected using immunofluorescence. Calcium concentration was determined using immunofluorescence and a fluorescence microplate reader. The levels of PI3K, p‐AKT and P‐STAT3 were assessed via WB and immunofluorescence. Results Compared to the IT group, the level of SCARF1 was significantly decreased in the AR group. Overexpression of SCARF1 in KCs improved AR and liver function markers. Enhanced phagocytosis mediated by SCARF1 is beneficial for improving the apoptotic clearance of AR and promoting M2 polarization of KCs. SCARF1‐mediated enhancement of phagocytosis promotes increased calcium concentration in KCs, thus further activating the PI3K‐AKT‐STAT3 signalling pathway. Conclusions SCARF1 promotes the M2 polarization of KCs by promoting phagocytosis through the calcium‐dependent PI3K‐AKT‐STAT3 signalling pathway." @default.
• W3135317966 created "2021-03-15" @default.
• W3135317966 creator A5027574938 @default.
• W3135317966 creator A5036176693 @default.
• W3135317966 creator A5043294576 @default.
• W3135317966 creator A5052679781 @default.
• W3135317966 creator A5068529751 @default.
• W3135317966 creator A5075676648 @default.
• W3135317966 creator A5076354526 @default.
• W3135317966 date "2021-03-09" @default.
• W3135317966 modified "2023-10-17" @default.
• W3135317966 title "SCARF1 promotes M2 polarization of Kupffer cells via calcium‐dependent PI3K‐AKT‐STAT3 signalling to improve liver transplantation" @default.
• W3135317966 cites W1758370979 @default.
• W3135317966 cites W1871390418 @default.
• W3135317966 cites W1919712230 @default.
• W3135317966 cites W1975031413 @default.
• W3135317966 cites W2023036885 @default.
• W3135317966 cites W2038709381 @default.
• W3135317966 cites W2041651305 @default.
• W3135317966 cites W2067843805 @default.
• W3135317966 cites W2091512770 @default.
• W3135317966 cites W2119305519 @default.
• W3135317966 cites W2126956583 @default.
• W3135317966 cites W2130486648 @default.
• W3135317966 cites W2132863746 @default.
• W3135317966 cites W2159560463 @default.
• W3135317966 cites W2162645937 @default.
• W3135317966 cites W2207821817 @default.
• W3135317966 cites W2209848665 @default.
• W3135317966 cites W2215274411 @default.
• W3135317966 cites W2345827332 @default.
• W3135317966 cites W2402118151 @default.
• W3135317966 cites W2469826089 @default.
• W3135317966 cites W2636131768 @default.
• W3135317966 cites W2782133916 @default.
• W3135317966 cites W2793689165 @default.
• W3135317966 cites W2800526280 @default.
• W3135317966 cites W2802807098 @default.
• W3135317966 cites W2807148066 @default.
• W3135317966 cites W2888607378 @default.
• W3135317966 cites W2892082076 @default.
• W3135317966 cites W2894175986 @default.
• W3135317966 cites W2909321035 @default.
• W3135317966 cites W2912273786 @default.
• W3135317966 cites W2922456202 @default.
• W3135317966 cites W2936586838 @default.
• W3135317966 cites W2945362170 @default.
• W3135317966 cites W2960355581 @default.
• W3135317966 cites W2972185292 @default.
• W3135317966 cites W3037161258 @default.
• W3135317966 cites W4236281756 @default.
• W3135317966 cites W785362024 @default.
• W3135317966 doi "https://doi.org/10.1111/cpr.13022" @default.
• W3135317966 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8016636" @default.
• W3135317966 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33686740" @default.
• W3135317966 hasPublicationYear "2021" @default.
• W3135317966 type Work @default.
• W3135317966 sameAs 3135317966 @default.
• W3135317966 citedByCount "12" @default.
• W3135317966 countsByYear W31353179662021 @default.
• W3135317966 countsByYear W31353179662022 @default.
• W3135317966 countsByYear W31353179662023 @default.
• W3135317966 crossrefType "journal-article" @default.
• W3135317966 hasAuthorship W3135317966A5027574938 @default.
• W3135317966 hasAuthorship W3135317966A5036176693 @default.
• W3135317966 hasAuthorship W3135317966A5043294576 @default.
• W3135317966 hasAuthorship W3135317966A5052679781 @default.
• W3135317966 hasAuthorship W3135317966A5068529751 @default.
• W3135317966 hasAuthorship W3135317966A5075676648 @default.
• W3135317966 hasAuthorship W3135317966A5076354526 @default.
• W3135317966 hasBestOaLocation W31353179662 @default.
• W3135317966 hasConcept C126322002 @default.
• W3135317966 hasConcept C153911025 @default.
• W3135317966 hasConcept C159654299 @default.
• W3135317966 hasConcept C160448771 @default.
• W3135317966 hasConcept C185592680 @default.
• W3135317966 hasConcept C190283241 @default.
• W3135317966 hasConcept C196795494 @default.
• W3135317966 hasConcept C203014093 @default.
• W3135317966 hasConcept C2778236600 @default.
• W3135317966 hasConcept C2911091166 @default.
• W3135317966 hasConcept C502942594 @default.
• W3135317966 hasConcept C55493867 @default.
• W3135317966 hasConcept C62478195 @default.
• W3135317966 hasConcept C71924100 @default.
• W3135317966 hasConcept C75217442 @default.
• W3135317966 hasConcept C86554907 @default.
• W3135317966 hasConcept C86803240 @default.
• W3135317966 hasConcept C95444343 @default.
• W3135317966 hasConceptScore W3135317966C126322002 @default.
• W3135317966 hasConceptScore W3135317966C153911025 @default.
• W3135317966 hasConceptScore W3135317966C159654299 @default.
• W3135317966 hasConceptScore W3135317966C160448771 @default.
• W3135317966 hasConceptScore W3135317966C185592680 @default.
• W3135317966 hasConceptScore W3135317966C190283241 @default.
• W3135317966 hasConceptScore W3135317966C196795494 @default.
• W3135317966 hasConceptScore W3135317966C203014093 @default.
• W3135317966 hasConceptScore W3135317966C2778236600 @default.
• W3135317966 hasConceptScore W3135317966C2911091166 @default.
• W3135317966 hasConceptScore W3135317966C502942594 @default.

• next