FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3135327883> ?p ?o ?g. }

• W3135327883 abstract "Glioblastoma (GBM) remains one of the most lethal primary brain tumors in both adult and pediatric patients. Targeting tumor metabolism has emerged as a promising-targeted therapeutic strategy for GBM and characteristically resistant GBM stem-like cells (GSCs). Neoplastic cells, especially those with high proliferative potential such as GSCs, have been shown to upregulate UCP2 as a cytoprotective mechanism in response to chronic increased reactive oxygen species (ROS) exposure. This upregulation plays a central role in the induction of the highly glycolytic phenotype associated with many tumors. In addition to shifting metabolism away from oxidative phosphorylation, UCP2 has also been implicated in increased mitochondrial Ca 2+ sequestration, apoptotic evasion, dampened immune response, and chemotherapeutic resistance. A query of the CGGA RNA-seq and the TCGA GBMLGG database demonstrated that UCP2 expression increases with increased WHO tumor-grade and is associated with much poorer prognosis across a cohort of brain tumors. UCP2 expression could potentially serve as a biomarker to stratify patients for adjunctive anti-tumor metabolic therapies, such as glycolytic inhibition alongside current standard of care, particularly in adult and pediatric gliomas. Additionally, because UCP2 correlates with tumor grade, monitoring serum protein levels in the future may allow clinicians a relatively minimally invasive marker to correlate with disease progression. Further investigation of UCP2’s role in metabolic reprogramming is warranted to fully appreciate its clinical translatability and utility." @default.
• W3135327883 created "2021-03-15" @default.
• W3135327883 creator A5044320554 @default.
• W3135327883 creator A5080953538 @default.
• W3135327883 creator A5090942584 @default.
• W3135327883 date "2021-03-08" @default.
• W3135327883 modified "2023-10-13" @default.
• W3135327883 title "UCP2 as a Potential Biomarker for Adjunctive Metabolic Therapies in Tumor Management" @default.
• W3135327883 cites W1594539479 @default.
• W3135327883 cites W1853519360 @default.
• W3135327883 cites W1978336416 @default.
• W3135327883 cites W1986399270 @default.
• W3135327883 cites W1988803699 @default.
• W3135327883 cites W1998564562 @default.
• W3135327883 cites W2006889378 @default.
• W3135327883 cites W2028371869 @default.
• W3135327883 cites W2032999577 @default.
• W3135327883 cites W2034296623 @default.
• W3135327883 cites W2034872735 @default.
• W3135327883 cites W2036573181 @default.
• W3135327883 cites W2041162408 @default.
• W3135327883 cites W2041962318 @default.
• W3135327883 cites W2049284715 @default.
• W3135327883 cites W2049903091 @default.
• W3135327883 cites W2062515127 @default.
• W3135327883 cites W2076598575 @default.
• W3135327883 cites W2077895077 @default.
• W3135327883 cites W2079797200 @default.
• W3135327883 cites W2089347873 @default.
• W3135327883 cites W2094094332 @default.
• W3135327883 cites W2097918979 @default.
• W3135327883 cites W2101651261 @default.
• W3135327883 cites W2101870887 @default.
• W3135327883 cites W2102322990 @default.
• W3135327883 cites W2102364504 @default.
• W3135327883 cites W2109748156 @default.
• W3135327883 cites W2111889825 @default.
• W3135327883 cites W2117692326 @default.
• W3135327883 cites W2119239003 @default.
• W3135327883 cites W2120741465 @default.
• W3135327883 cites W2125685767 @default.
• W3135327883 cites W2131387907 @default.
• W3135327883 cites W2133486230 @default.
• W3135327883 cites W2134466068 @default.
• W3135327883 cites W2139896878 @default.
• W3135327883 cites W2160176350 @default.
• W3135327883 cites W2194570961 @default.
• W3135327883 cites W2221217582 @default.
• W3135327883 cites W2270045920 @default.
• W3135327883 cites W2322577820 @default.
• W3135327883 cites W2324842340 @default.
• W3135327883 cites W2548475758 @default.
• W3135327883 cites W2554863679 @default.
• W3135327883 cites W2582285180 @default.
• W3135327883 cites W2585957979 @default.
• W3135327883 cites W2751637972 @default.
• W3135327883 cites W2754515846 @default.
• W3135327883 cites W2763082101 @default.
• W3135327883 cites W2914214085 @default.
• W3135327883 cites W2917271898 @default.
• W3135327883 cites W2920394342 @default.
• W3135327883 cites W2921291894 @default.
• W3135327883 cites W2924489416 @default.
• W3135327883 cites W2983341556 @default.
• W3135327883 cites W2987962979 @default.
• W3135327883 cites W2992862355 @default.
• W3135327883 cites W2996587746 @default.
• W3135327883 cites W3006674130 @default.
• W3135327883 cites W3008847232 @default.
• W3135327883 cites W3028777249 @default.
• W3135327883 cites W3028948122 @default.
• W3135327883 cites W3093418318 @default.
• W3135327883 cites W3099246654 @default.
• W3135327883 cites W3120989053 @default.
• W3135327883 cites W4211220688 @default.
• W3135327883 cites W4230172521 @default.
• W3135327883 doi "https://doi.org/10.3389/fonc.2021.640720" @default.
• W3135327883 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7982524" @default.
• W3135327883 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33763373" @default.
• W3135327883 hasPublicationYear "2021" @default.
• W3135327883 type Work @default.
• W3135327883 sameAs 3135327883 @default.
• W3135327883 citedByCount "10" @default.
• W3135327883 countsByYear W31353278832021 @default.
• W3135327883 countsByYear W31353278832022 @default.
• W3135327883 countsByYear W31353278832023 @default.
• W3135327883 crossrefType "journal-article" @default.
• W3135327883 hasAuthorship W3135327883A5044320554 @default.
• W3135327883 hasAuthorship W3135327883A5080953538 @default.
• W3135327883 hasAuthorship W3135327883A5090942584 @default.
• W3135327883 hasBestOaLocation W31353278831 @default.
• W3135327883 hasConcept C104317684 @default.
• W3135327883 hasConcept C121608353 @default.
• W3135327883 hasConcept C126322002 @default.
• W3135327883 hasConcept C127561419 @default.
• W3135327883 hasConcept C143998085 @default.
• W3135327883 hasConcept C1491633281 @default.
• W3135327883 hasConcept C20251656 @default.
• W3135327883 hasConcept C2778227246 @default.
• W3135327883 hasConcept C2781197716 @default.

• next