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• W3135358879 abstract "Abstract Treatment of advanced melanoma with combined PD-1/CTLA-4 blockade commonly causes serious immune-mediated complications. Here, we identify a subset of patients predisposed to immune checkpoint blockade-related hepatitis who are distinguished by chronic expansion of effector memory CD4 + T cells (T EM cells). Pre-therapy CD4 + T EM cell expansion occurs primarily during autumn or winter in patients with metastatic disease and high cytomegalovirus (CMV)-specific serum antibody titres. These clinical features implicate metastasis-dependent, compartmentalised CMV reactivation as the cause of CD4 + T EM expansion. Pre-therapy CD4 + T EM expansion predicts hepatitis in CMV-seropositive patients, opening possibilities for avoidance or prevention. 3 of 4 patients with pre-treatment CD4 + T EM expansion who received αPD-1 monotherapy instead of αPD-1/αCTLA-4 therapy remained hepatitis-free. 4 of 4 patients with baseline CD4 + T EM expansion given prophylactic valganciclovir and αPD-1/αCTLA-4 therapy remained hepatitis-free. Our findings exemplify how pathogen exposure can shape clinical reactions after cancer therapy and how this insight leads to therapeutic innovations." @default.
• W3135358879 created "2021-03-15" @default.
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• W3135358879 date "2021-03-04" @default.
• W3135358879 modified "2023-10-15" @default.
• W3135358879 title "Virus-specific memory T cell responses unmasked by immune checkpoint blockade cause hepatitis" @default.
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• W3135358879 doi "https://doi.org/10.1038/s41467-021-21572-y" @default.
• W3135358879 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7933278" @default.
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• W3135358879 hasPublicationYear "2021" @default.
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