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• W3135393637 startingPage "4453" @default.
• W3135393637 abstract "Abstract Transactive response DNA-binding protein 43 kDa (TDP-43) encoded by the TARDBP gene is an evolutionarily conserved heterogeneous nuclear ribonucleoprotein (hnRNP) that regulates multiple steps of RNA metabolism, and its cytoplasmic aggregation characterizes degenerating motor neurons in amyotrophic lateral sclerosis (ALS). In most ALS cases, cytoplasmic TDP-43 aggregation occurs in the absence of mutations in the coding sequence of TARDBP . Thus, a major challenge in ALS research is to understand the nature of pathological changes occurring in wild-type TDP-43 and to explore upstream events in intracellular and extracellular milieu that promote the pathological transition of TDP-43. Despite the inherent obstacles to analyzing TDP-43 dynamics in in vivo motor neurons due to their anatomical complexity and inaccessibility, recent studies using cellular and animal models have provided important mechanistic insights into potential links between TDP-43 and motor neuron vulnerability in ALS. This review is intended to provide an overview of the current literature on the function and regulation of TDP-43-containing RNP granules or membraneless organelles, as revealed by various models, and to discuss the potential mechanisms by which TDP-43 can cause selective vulnerability of motor neurons in ALS." @default.
• W3135393637 created "2021-03-15" @default.
• W3135393637 creator A5003488464 @default.
• W3135393637 creator A5011870789 @default.
• W3135393637 creator A5034882455 @default.
• W3135393637 date "2021-03-11" @default.
• W3135393637 modified "2023-10-07" @default.
• W3135393637 title "Multi-phaseted problems of TDP-43 in selective neuronal vulnerability in ALS" @default.
• W3135393637 cites W1533438796 @default.
• W3135393637 cites W1560299838 @default.
• W3135393637 cites W1894813487 @default.
• W3135393637 cites W1903544737 @default.
• W3135393637 cites W1966457081 @default.
• W3135393637 cites W1967443709 @default.
• W3135393637 cites W1967493869 @default.
• W3135393637 cites W1971639674 @default.
• W3135393637 cites W1974244619 @default.
• W3135393637 cites W1983335981 @default.
• W3135393637 cites W1984145170 @default.
• W3135393637 cites W1988931872 @default.
• W3135393637 cites W1997568572 @default.
• W3135393637 cites W1999522052 @default.
• W3135393637 cites W2003618511 @default.
• W3135393637 cites W2006938672 @default.
• W3135393637 cites W2010029946 @default.
• W3135393637 cites W2011396520 @default.
• W3135393637 cites W2014127990 @default.
• W3135393637 cites W2020845980 @default.
• W3135393637 cites W2023166679 @default.
• W3135393637 cites W2024351685 @default.
• W3135393637 cites W2024715297 @default.
• W3135393637 cites W2026931179 @default.
• W3135393637 cites W2027720028 @default.
• W3135393637 cites W2029553530 @default.
• W3135393637 cites W2029880255 @default.
• W3135393637 cites W2031964319 @default.
• W3135393637 cites W2032719480 @default.
• W3135393637 cites W2037027251 @default.
• W3135393637 cites W2038555363 @default.
• W3135393637 cites W2041451000 @default.
• W3135393637 cites W2042396829 @default.
• W3135393637 cites W2043042906 @default.
• W3135393637 cites W2043448850 @default.
• W3135393637 cites W2044963576 @default.
• W3135393637 cites W2045602910 @default.
• W3135393637 cites W2046353863 @default.
• W3135393637 cites W2046641567 @default.
• W3135393637 cites W2047850449 @default.
• W3135393637 cites W2055045552 @default.
• W3135393637 cites W2064801746 @default.
• W3135393637 cites W2065139981 @default.
• W3135393637 cites W2066075373 @default.
• W3135393637 cites W2066088939 @default.
• W3135393637 cites W2067772208 @default.
• W3135393637 cites W2071505821 @default.
• W3135393637 cites W2073073462 @default.
• W3135393637 cites W2079712894 @default.
• W3135393637 cites W2080620346 @default.
• W3135393637 cites W2082602037 @default.
• W3135393637 cites W2090612554 @default.
• W3135393637 cites W2093334504 @default.
• W3135393637 cites W2099956943 @default.
• W3135393637 cites W2101042581 @default.
• W3135393637 cites W2101776417 @default.
• W3135393637 cites W2102026369 @default.
• W3135393637 cites W2102898524 @default.
• W3135393637 cites W2103246829 @default.
• W3135393637 cites W2103739793 @default.
• W3135393637 cites W2106322477 @default.
• W3135393637 cites W2107338709 @default.
• W3135393637 cites W2108937907 @default.
• W3135393637 cites W2111796925 @default.
• W3135393637 cites W2112538318 @default.
• W3135393637 cites W2112710669 @default.
• W3135393637 cites W2116040140 @default.
• W3135393637 cites W2116660354 @default.
• W3135393637 cites W2117428493 @default.
• W3135393637 cites W2117692658 @default.
• W3135393637 cites W2121330845 @default.
• W3135393637 cites W2122427766 @default.
• W3135393637 cites W2124727655 @default.
• W3135393637 cites W2127856412 @default.
• W3135393637 cites W2132166526 @default.
• W3135393637 cites W2135466257 @default.
• W3135393637 cites W2135855797 @default.
• W3135393637 cites W2136949432 @default.
• W3135393637 cites W2139066576 @default.
• W3135393637 cites W2139267086 @default.
• W3135393637 cites W2140124588 @default.
• W3135393637 cites W2142924684 @default.
• W3135393637 cites W2143612940 @default.
• W3135393637 cites W2149497936 @default.
• W3135393637 cites W2154417593 @default.
• W3135393637 cites W2154923417 @default.
• W3135393637 cites W2159354359 @default.
• W3135393637 cites W2160051803 @default.
• W3135393637 cites W2160311330 @default.
• W3135393637 cites W2160858975 @default.

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