FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3135437061> ?p ?o ?g. }

• W3135437061 endingPage "486" @default.
• W3135437061 startingPage "475" @default.
• W3135437061 abstract "The purpose of this study was to develop a novel β-tricalcium phosphate (TCP)/poly (D,L-lactic-co-glycolic acid) (PLGA) composite scaffold loaded with rapamycin that can regulate the activity of osteoblasts and osteoclasts for lumbar fusion. The TCP/PLGA composite scaffold was fabricated by cryogenic three-dimensional printing techniques and then loaded with rapamycin in situ. The structural surface morphology of the composite scaffold was tested with scanning electron microscope. To evaluate the biocompatibility of the composite scaffold in vitro, bone marrow mesenchymal stem cells (BMSCs) were cultured on the TCP/PLGA composite scaffold slide and tested with Live/Dead Viability Kit. The effect of rapamycin on osteoclast and osteoblast was studied with staining and Western blotting. The in vitro results showed that the rapamycin-loaded TCP/PLGA composite scaffold showed good biocompatibility with BMSC and released rapamycin obviously promoted the osteoblast differentiation and mineralization. In vivo study, the TCP/PLGA composite scaffold loaded with rapamycin were implanted in lumbar fusion model and study with micro-computed tomography scanning, hematoxylin-eosin, Masson, and immune-histological staining, to evaluate the effect of rapamycin on bone fusion. The in vivo results demonstrated that rapamycin-loaded TCP/PLGA composite scaffold could enhance bone formation by regulating osteoblast and osteoclast activity, respectively. In this study, the TCP/PLGA composite scaffold loaded with rapamycin was confirmed to provide great compatibility and improved performance in lumbar fusion by regulating osteoblastic and osteoclastic activity and would be a promising composite biomaterial for bone tissue engineering." @default.
• W3135437061 created "2021-03-15" @default.
• W3135437061 creator A5000432967 @default.
• W3135437061 creator A5002739368 @default.
• W3135437061 creator A5002790856 @default.
• W3135437061 creator A5009673650 @default.
• W3135437061 creator A5018768725 @default.
• W3135437061 creator A5027950584 @default.
• W3135437061 creator A5031220745 @default.
• W3135437061 creator A5039684004 @default.
• W3135437061 creator A5041291289 @default.
• W3135437061 creator A5043052947 @default.
• W3135437061 creator A5047525800 @default.
• W3135437061 creator A5049172276 @default.
• W3135437061 creator A5049344404 @default.
• W3135437061 creator A5079701078 @default.
• W3135437061 creator A5086694391 @default.
• W3135437061 date "2021-04-19" @default.
• W3135437061 modified "2023-10-14" @default.
• W3135437061 title "TCP/PLGA composite scaffold loaded rapamycin in situ enhances lumbar fusion by regulating osteoblast and osteoclast activity" @default.
• W3135437061 cites W1013158645 @default.
• W3135437061 cites W1971059872 @default.
• W3135437061 cites W1971955679 @default.
• W3135437061 cites W2007310752 @default.
• W3135437061 cites W2008890078 @default.
• W3135437061 cites W2011328641 @default.
• W3135437061 cites W2026430387 @default.
• W3135437061 cites W2027725351 @default.
• W3135437061 cites W2028079449 @default.
• W3135437061 cites W2041141449 @default.
• W3135437061 cites W2044640123 @default.
• W3135437061 cites W2049089797 @default.
• W3135437061 cites W2110068403 @default.
• W3135437061 cites W2111567059 @default.
• W3135437061 cites W2142361560 @default.
• W3135437061 cites W2143135065 @default.
• W3135437061 cites W2155809545 @default.
• W3135437061 cites W2162048559 @default.
• W3135437061 cites W2241848110 @default.
• W3135437061 cites W2334503699 @default.
• W3135437061 cites W2337634448 @default.
• W3135437061 cites W2341397583 @default.
• W3135437061 cites W2586307201 @default.
• W3135437061 cites W2597986221 @default.
• W3135437061 cites W2611181230 @default.
• W3135437061 cites W2614079712 @default.
• W3135437061 cites W2615206886 @default.
• W3135437061 cites W2626451207 @default.
• W3135437061 cites W2740226484 @default.
• W3135437061 cites W2761458527 @default.
• W3135437061 cites W2762605834 @default.
• W3135437061 cites W2770629095 @default.
• W3135437061 cites W2791007378 @default.
• W3135437061 cites W2799572394 @default.
• W3135437061 cites W2803217716 @default.
• W3135437061 cites W2885891296 @default.
• W3135437061 cites W2888029217 @default.
• W3135437061 cites W2889673843 @default.
• W3135437061 cites W2889742898 @default.
• W3135437061 cites W2894395266 @default.
• W3135437061 cites W2904505507 @default.
• W3135437061 cites W2907401739 @default.
• W3135437061 cites W2935288345 @default.
• W3135437061 cites W2938794715 @default.
• W3135437061 cites W2941758647 @default.
• W3135437061 cites W2961742920 @default.
• W3135437061 cites W2972629861 @default.
• W3135437061 cites W3011922163 @default.
• W3135437061 cites W3094184478 @default.
• W3135437061 doi "https://doi.org/10.1002/term.3186" @default.
• W3135437061 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33686790" @default.
• W3135437061 hasPublicationYear "2021" @default.
• W3135437061 type Work @default.
• W3135437061 sameAs 3135437061 @default.
• W3135437061 citedByCount "3" @default.
• W3135437061 countsByYear W31354370612022 @default.
• W3135437061 countsByYear W31354370612023 @default.
• W3135437061 crossrefType "journal-article" @default.
• W3135437061 hasAuthorship W3135437061A5000432967 @default.
• W3135437061 hasAuthorship W3135437061A5002739368 @default.
• W3135437061 hasAuthorship W3135437061A5002790856 @default.
• W3135437061 hasAuthorship W3135437061A5009673650 @default.
• W3135437061 hasAuthorship W3135437061A5018768725 @default.
• W3135437061 hasAuthorship W3135437061A5027950584 @default.
• W3135437061 hasAuthorship W3135437061A5031220745 @default.
• W3135437061 hasAuthorship W3135437061A5039684004 @default.
• W3135437061 hasAuthorship W3135437061A5041291289 @default.
• W3135437061 hasAuthorship W3135437061A5043052947 @default.
• W3135437061 hasAuthorship W3135437061A5047525800 @default.
• W3135437061 hasAuthorship W3135437061A5049172276 @default.
• W3135437061 hasAuthorship W3135437061A5049344404 @default.
• W3135437061 hasAuthorship W3135437061A5079701078 @default.
• W3135437061 hasAuthorship W3135437061A5086694391 @default.
• W3135437061 hasBestOaLocation W31354370611 @default.
• W3135437061 hasConcept C136229726 @default.
• W3135437061 hasConcept C178790620 @default.
• W3135437061 hasConcept C185592680 @default.
• W3135437061 hasConcept C192562407 @default.

• next