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- W3135468128 abstract "Although much progress has been made in the treatment of multiple myeloma, the majority of patients fail to be cured and require numerous lines of therapy. Inhibitors of the BCL2 family represent an exciting new class of drugs with a novel mechanism of action that are likely to have activity as single agents and in combination with existing myeloma therapies. The BCL2 proteins are oncogenes that promote cell survival and are frequently upregulated in multiple myeloma, making them attractive targets. Venetoclax, a BCL2 specific inhibitor, is furthest along in development and has shown promising results in a subset of myeloma characterized by the t(11;14) translocation. Combining venetoclax with proteasome inhibitors and monoclonal antibodies has improved responses in a broader group of patients, but has come at the expense of a toxicity safety signal that requires additional follow-up. MCL1 inhibitors are likely to be effective in a broader range of patients and are currently in early clinical trials. This review will cover much of what is known about the biology of these drugs, biomarkers that predict response, mechanisms of resistance, and unanswered questions as they pertain to multiple myeloma." @default.
- W3135468128 created "2021-03-15" @default.
- W3135468128 creator A5038076013 @default.
- W3135468128 creator A5046430988 @default.
- W3135468128 creator A5077897003 @default.
- W3135468128 creator A5081627623 @default.
- W3135468128 date "2021-03-01" @default.
- W3135468128 modified "2023-10-12" @default.
- W3135468128 title "BCL2 Family Inhibitors in the Biology and Treatment of Multiple Myeloma" @default.
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- W3135468128 doi "https://doi.org/10.2147/blctt.s245191" @default.
- W3135468128 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7965688" @default.
- W3135468128 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33737856" @default.
- W3135468128 hasPublicationYear "2021" @default.
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