Matches in SemOpenAlex for { <https://semopenalex.org/work/W3135495654> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W3135495654 endingPage "1757" @default.
- W3135495654 startingPage "1749" @default.
- W3135495654 abstract "The treatment of gout with allopurinol is effective at reducing urate levels and the frequency of flares. Several observational studies have shown important reductions in mortality with allopurinol use, with wide variations in results. We undertook this review to assess the extent of bias in these studies, particularly time-related biases such as immortal time bias.We searched the literature to identify all observational studies describing the effect of allopurinol use versus nonuse on all-cause mortality.We identified 12 observational studies, of which 3 were affected by immortal time bias and 3 by immeasurable time bias, while the remaining 6 studies avoided these time-related biases. Reductions in all-cause mortality with allopurinol use were observed among the studies with immortal time bias, with a pooled hazard ratio (HR) of death associated with allopurinol of 0.71 (95% confidence interval [95% CI] 0.50-1.01), as well as in those with immeasurable time bias (pooled HR 0.62 [95% CI 0.56-0.67]). The 6 studies that avoided these biases demonstrated a null effect of allopurinol on mortality (pooled HR 0.99 [95% CI 0.87-1.11]), though the lack of an analysis based on treatment adherence may have attenuated the effect.Observational studies are important to provide real-world data on medication effects. The observational studies showing significantly decreased mortality with allopurinol treatment cannot be used as evidence, however, mainly due to time-related biases that tend to greatly exaggerate the potential benefit of treatments. The ALL-HEART randomized trial, which is currently underway and evaluates the effect of adding allopurinol to usual care (compared to no added treatment), will provide reliable evidence on mortality." @default.
- W3135495654 created "2021-03-15" @default.
- W3135495654 creator A5008217187 @default.
- W3135495654 creator A5020242261 @default.
- W3135495654 creator A5020983255 @default.
- W3135495654 date "2021-07-27" @default.
- W3135495654 modified "2023-09-26" @default.
- W3135495654 title "Effectiveness of Allopurinol in Reducing Mortality: Time‐Related Biases in Observational Studies" @default.
- W3135495654 cites W1934958750 @default.
- W3135495654 cites W1965907452 @default.
- W3135495654 cites W2004261324 @default.
- W3135495654 cites W2004753352 @default.
- W3135495654 cites W2056212662 @default.
- W3135495654 cites W2092965345 @default.
- W3135495654 cites W2094456585 @default.
- W3135495654 cites W2103608778 @default.
- W3135495654 cites W2111714917 @default.
- W3135495654 cites W2112488677 @default.
- W3135495654 cites W2117317003 @default.
- W3135495654 cites W2134073450 @default.
- W3135495654 cites W2135197165 @default.
- W3135495654 cites W2142006483 @default.
- W3135495654 cites W2159801354 @default.
- W3135495654 cites W2163333582 @default.
- W3135495654 cites W2177441987 @default.
- W3135495654 cites W2404984931 @default.
- W3135495654 cites W2510649347 @default.
- W3135495654 cites W2519686100 @default.
- W3135495654 cites W2560688864 @default.
- W3135495654 cites W2580127675 @default.
- W3135495654 cites W2761269929 @default.
- W3135495654 cites W2770988310 @default.
- W3135495654 cites W2787245380 @default.
- W3135495654 cites W2805828290 @default.
- W3135495654 cites W2912391401 @default.
- W3135495654 cites W2921493506 @default.
- W3135495654 cites W2998636556 @default.
- W3135495654 cites W3023256684 @default.
- W3135495654 cites W3023950690 @default.
- W3135495654 cites W3048846123 @default.
- W3135495654 cites W3113480125 @default.
- W3135495654 doi "https://doi.org/10.1002/art.41710" @default.
- W3135495654 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33645906" @default.
- W3135495654 hasPublicationYear "2021" @default.
- W3135495654 type Work @default.
- W3135495654 sameAs 3135495654 @default.
- W3135495654 citedByCount "11" @default.
- W3135495654 countsByYear W31354956542021 @default.
- W3135495654 countsByYear W31354956542022 @default.
- W3135495654 countsByYear W31354956542023 @default.
- W3135495654 crossrefType "journal-article" @default.
- W3135495654 hasAuthorship W3135495654A5008217187 @default.
- W3135495654 hasAuthorship W3135495654A5020242261 @default.
- W3135495654 hasAuthorship W3135495654A5020983255 @default.
- W3135495654 hasConcept C126322002 @default.
- W3135495654 hasConcept C144024400 @default.
- W3135495654 hasConcept C149923435 @default.
- W3135495654 hasConcept C168563851 @default.
- W3135495654 hasConcept C207103383 @default.
- W3135495654 hasConcept C23131810 @default.
- W3135495654 hasConcept C2780261098 @default.
- W3135495654 hasConcept C2780402116 @default.
- W3135495654 hasConcept C2780439572 @default.
- W3135495654 hasConcept C44249647 @default.
- W3135495654 hasConcept C71924100 @default.
- W3135495654 hasConcept C95190672 @default.
- W3135495654 hasConceptScore W3135495654C126322002 @default.
- W3135495654 hasConceptScore W3135495654C144024400 @default.
- W3135495654 hasConceptScore W3135495654C149923435 @default.
- W3135495654 hasConceptScore W3135495654C168563851 @default.
- W3135495654 hasConceptScore W3135495654C207103383 @default.
- W3135495654 hasConceptScore W3135495654C23131810 @default.
- W3135495654 hasConceptScore W3135495654C2780261098 @default.
- W3135495654 hasConceptScore W3135495654C2780402116 @default.
- W3135495654 hasConceptScore W3135495654C2780439572 @default.
- W3135495654 hasConceptScore W3135495654C44249647 @default.
- W3135495654 hasConceptScore W3135495654C71924100 @default.
- W3135495654 hasConceptScore W3135495654C95190672 @default.
- W3135495654 hasIssue "9" @default.
- W3135495654 hasLocation W31354956541 @default.
- W3135495654 hasLocation W31354956542 @default.
- W3135495654 hasOpenAccess W3135495654 @default.
- W3135495654 hasPrimaryLocation W31354956541 @default.
- W3135495654 hasRelatedWork W1948064258 @default.
- W3135495654 hasRelatedWork W2177441987 @default.
- W3135495654 hasRelatedWork W2286371484 @default.
- W3135495654 hasRelatedWork W2531052508 @default.
- W3135495654 hasRelatedWork W2889691785 @default.
- W3135495654 hasRelatedWork W3135495654 @default.
- W3135495654 hasRelatedWork W4246785167 @default.
- W3135495654 hasRelatedWork W4288046937 @default.
- W3135495654 hasRelatedWork W4320519634 @default.
- W3135495654 hasRelatedWork W67887746 @default.
- W3135495654 hasVolume "73" @default.
- W3135495654 isParatext "false" @default.
- W3135495654 isRetracted "false" @default.
- W3135495654 magId "3135495654" @default.
- W3135495654 workType "article" @default.