FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3135508386> ?p ?o ?g. }

• W3135508386 abstract "Abstract The study examines the whole blood transcriptome profile before and after cardiopulmonary bypass (CPB) in neonates with hypoplastic left heart syndrome (HLHS), a severe form of congenital heart disease, that can develop low cardiac output syndrome (LCOS). Whole blood mRNA transcriptome profiles of 13 neonates with HLHS before and after their first palliative surgery were analyzed to determine differentially expressed genes and pathways. The median age and weight at surgery were 4 days and 3.2 kg, respectively. Of the 13 patients, 8 developed LCOS. There was no significant difference between CPB, aortic cross clamp, deep hypothermic cardiac arrest times between patients that develop LCOS and those that do not. Upon comparing differential gene expression profiles between patients that develop LCOS and those that do not in pre-operative samples, 1 gene was up-regulated and 13 were down regulated. In the post-operative samples, 4 genes were up-regulated, and 4 genes were down regulated when patients that develop LCOS were compared to those that do not. When comparing post-operative samples to pre-operative samples in the patients that do not develop LCOS, 1484 genes were up-regulated, and 1388 genes were down regulated; while patients that developed LCOS had 2423 up-regulated genes, and 2414 down regulated genes for the same pre to post-operative comparison. Pathway analysis revealed differential regulation of inflammatory pathways (IL signaling, PDGF, NOTCH1, NGF, GPCR) and metabolic pathways (heme metabolism, oxidative phosphorylation, protein metabolism including amino acid and derivatives, fatty acid metabolism, TCA cycle and respiratory electron transport chain). By identifying altered transcriptome profiles related to inflammation and metabolism in neonates with HLHS who develop LCOS after CPB, this study opens for exploration novel pathways and potential therapeutic targets to improve outcomes in this high-risk population." @default.
• W3135508386 created "2021-03-15" @default.
• W3135508386 creator A5008920118 @default.
• W3135508386 creator A5020048782 @default.
• W3135508386 creator A5036929595 @default.
• W3135508386 creator A5052319319 @default.
• W3135508386 creator A5052755605 @default.
• W3135508386 creator A5072207917 @default.
• W3135508386 creator A5074659229 @default.
• W3135508386 creator A5085230748 @default.
• W3135508386 creator A5090456011 @default.
• W3135508386 date "2021-03-02" @default.
• W3135508386 modified "2023-10-07" @default.
• W3135508386 title "Altered metabolic and inflammatory transcriptomics after cardiac surgery in neonates with congenital heart disease" @default.
• W3135508386 cites W1482244404 @default.
• W3135508386 cites W1555165785 @default.
• W3135508386 cites W1640223910 @default.
• W3135508386 cites W1978240058 @default.
• W3135508386 cites W1979556773 @default.
• W3135508386 cites W1980327088 @default.
• W3135508386 cites W1982082299 @default.
• W3135508386 cites W2000007666 @default.
• W3135508386 cites W2002876223 @default.
• W3135508386 cites W2012517517 @default.
• W3135508386 cites W2013652464 @default.
• W3135508386 cites W2027964705 @default.
• W3135508386 cites W2029422437 @default.
• W3135508386 cites W2036897871 @default.
• W3135508386 cites W2039521726 @default.
• W3135508386 cites W2043845684 @default.
• W3135508386 cites W2044227662 @default.
• W3135508386 cites W2071518542 @default.
• W3135508386 cites W2075318595 @default.
• W3135508386 cites W2079492007 @default.
• W3135508386 cites W2081592657 @default.
• W3135508386 cites W2086731047 @default.
• W3135508386 cites W2108234281 @default.
• W3135508386 cites W2114104545 @default.
• W3135508386 cites W2123106337 @default.
• W3135508386 cites W2128499865 @default.
• W3135508386 cites W2130410032 @default.
• W3135508386 cites W2138207763 @default.
• W3135508386 cites W2138373808 @default.
• W3135508386 cites W2141900287 @default.
• W3135508386 cites W2145755531 @default.
• W3135508386 cites W2158804744 @default.
• W3135508386 cites W2167904436 @default.
• W3135508386 cites W2179438025 @default.
• W3135508386 cites W2252905246 @default.
• W3135508386 cites W2321258598 @default.
• W3135508386 cites W2401411142 @default.
• W3135508386 cites W2510875395 @default.
• W3135508386 cites W2513181318 @default.
• W3135508386 cites W2601159453 @default.
• W3135508386 cites W2904429416 @default.
• W3135508386 cites W2964403236 @default.
• W3135508386 cites W3001363353 @default.
• W3135508386 doi "https://doi.org/10.1038/s41598-021-83882-x" @default.
• W3135508386 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7925649" @default.
• W3135508386 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33654130" @default.
• W3135508386 hasPublicationYear "2021" @default.
• W3135508386 type Work @default.
• W3135508386 sameAs 3135508386 @default.
• W3135508386 citedByCount "3" @default.
• W3135508386 countsByYear W31355083862021 @default.
• W3135508386 countsByYear W31355083862022 @default.
• W3135508386 countsByYear W31355083862023 @default.
• W3135508386 crossrefType "journal-article" @default.
• W3135508386 hasAuthorship W3135508386A5008920118 @default.
• W3135508386 hasAuthorship W3135508386A5020048782 @default.
• W3135508386 hasAuthorship W3135508386A5036929595 @default.
• W3135508386 hasAuthorship W3135508386A5052319319 @default.
• W3135508386 hasAuthorship W3135508386A5052755605 @default.
• W3135508386 hasAuthorship W3135508386A5072207917 @default.
• W3135508386 hasAuthorship W3135508386A5074659229 @default.
• W3135508386 hasAuthorship W3135508386A5085230748 @default.
• W3135508386 hasAuthorship W3135508386A5090456011 @default.
• W3135508386 hasBestOaLocation W31355083861 @default.
• W3135508386 hasConcept C104317684 @default.
• W3135508386 hasConcept C126322002 @default.
• W3135508386 hasConcept C150194340 @default.
• W3135508386 hasConcept C162317418 @default.
• W3135508386 hasConcept C2778881276 @default.
• W3135508386 hasConcept C55493867 @default.
• W3135508386 hasConcept C71924100 @default.
• W3135508386 hasConcept C86803240 @default.
• W3135508386 hasConceptScore W3135508386C104317684 @default.
• W3135508386 hasConceptScore W3135508386C126322002 @default.
• W3135508386 hasConceptScore W3135508386C150194340 @default.
• W3135508386 hasConceptScore W3135508386C162317418 @default.
• W3135508386 hasConceptScore W3135508386C2778881276 @default.
• W3135508386 hasConceptScore W3135508386C55493867 @default.
• W3135508386 hasConceptScore W3135508386C71924100 @default.
• W3135508386 hasConceptScore W3135508386C86803240 @default.
• W3135508386 hasFunder F4320306080 @default.
• W3135508386 hasFunder F4320332161 @default.
• W3135508386 hasFunder F4320337361 @default.
• W3135508386 hasIssue "1" @default.
• W3135508386 hasLocation W31355083861 @default.
• W3135508386 hasLocation W31355083862 @default.

• next