FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3135509888> ?p ?o ?g. }

• W3135509888 endingPage "391" @default.
• W3135509888 startingPage "381" @default.
• W3135509888 abstract "The monoaminergic neurotransmitters dopamine, noradrenaline, and serotonin are pivotal actors of the interplay between the nervous and the immune system due to their ability of binding to cell-receptors of both systems, crucially regulating their function within the central nervous system and the periphery. As monoamines are dysfunctional in many neurological and psychiatric diseases, they have been successfully used as pharmacological targets. Multiple sclerosis (MS) is one of the best examples of neurological disease caused by an altered interaction between the nervous and immune system and emerging evidence supports a dysregulation of monoaminergic systems in the pathogenesis of MS, secondary to both inflammation-induced reduction of monoamines’ synthesis and structural damage to monoaminergic pathways within the brain. Here we review the evidence for monoamines being key mediators of neuroimmune interaction, affecting MS pathogenesis and course. Moreover, we discuss how the reduction/dysfunction of monoamines in MS may contribute to some clinical features typical of the disease, particularly fatigue and depression. Finally, we summarize different drugs targeting monoamines that are currently under evaluation for their potential efficacy to treat MS, as well as to alleviate fatigue and depression in MS." @default.
• W3135509888 created "2021-03-15" @default.
• W3135509888 creator A5023350680 @default.
• W3135509888 creator A5032032723 @default.
• W3135509888 creator A5078205854 @default.
• W3135509888 creator A5081436063 @default.
• W3135509888 creator A5089549553 @default.
• W3135509888 date "2021-05-01" @default.
• W3135509888 modified "2023-09-23" @default.
• W3135509888 title "The distinct roles of monoamines in multiple sclerosis: A bridge between the immune and nervous systems?" @default.
• W3135509888 cites W1540636948 @default.
• W3135509888 cites W1855371734 @default.
• W3135509888 cites W1965395632 @default.
• W3135509888 cites W1968893068 @default.
• W3135509888 cites W1968984586 @default.
• W3135509888 cites W1969093378 @default.
• W3135509888 cites W1969610953 @default.
• W3135509888 cites W1971097064 @default.
• W3135509888 cites W1973717649 @default.
• W3135509888 cites W1975994431 @default.
• W3135509888 cites W1978493362 @default.
• W3135509888 cites W1982000977 @default.
• W3135509888 cites W1987183038 @default.
• W3135509888 cites W1988167173 @default.
• W3135509888 cites W1992017771 @default.
• W3135509888 cites W1994756246 @default.
• W3135509888 cites W2005139957 @default.
• W3135509888 cites W2006548108 @default.
• W3135509888 cites W2012836981 @default.
• W3135509888 cites W2021962531 @default.
• W3135509888 cites W2025623966 @default.
• W3135509888 cites W2026795289 @default.
• W3135509888 cites W2027671137 @default.
• W3135509888 cites W2032754105 @default.
• W3135509888 cites W2041532800 @default.
• W3135509888 cites W2049499319 @default.
• W3135509888 cites W2063665995 @default.
• W3135509888 cites W2074744814 @default.
• W3135509888 cites W2078020097 @default.
• W3135509888 cites W2078873559 @default.
• W3135509888 cites W2081186975 @default.
• W3135509888 cites W2081275823 @default.
• W3135509888 cites W2083623909 @default.
• W3135509888 cites W2084158898 @default.
• W3135509888 cites W2088936071 @default.
• W3135509888 cites W2089735092 @default.
• W3135509888 cites W2090544286 @default.
• W3135509888 cites W2098382378 @default.
• W3135509888 cites W2099979865 @default.
• W3135509888 cites W2105563190 @default.
• W3135509888 cites W2108535958 @default.
• W3135509888 cites W2110286470 @default.
• W3135509888 cites W2110421515 @default.
• W3135509888 cites W2114468018 @default.
• W3135509888 cites W2114718099 @default.
• W3135509888 cites W2117272607 @default.
• W3135509888 cites W2117530544 @default.
• W3135509888 cites W2130548940 @default.
• W3135509888 cites W2140362680 @default.
• W3135509888 cites W2155004232 @default.
• W3135509888 cites W2156801044 @default.
• W3135509888 cites W2196461303 @default.
• W3135509888 cites W2199553413 @default.
• W3135509888 cites W2270315281 @default.
• W3135509888 cites W2293281822 @default.
• W3135509888 cites W2296073419 @default.
• W3135509888 cites W2332549914 @default.
• W3135509888 cites W2343774919 @default.
• W3135509888 cites W2465360896 @default.
• W3135509888 cites W2474276886 @default.
• W3135509888 cites W2501157810 @default.
• W3135509888 cites W2518460556 @default.
• W3135509888 cites W2537420280 @default.
• W3135509888 cites W2572551054 @default.
• W3135509888 cites W2582555486 @default.
• W3135509888 cites W2589706235 @default.
• W3135509888 cites W2593011483 @default.
• W3135509888 cites W2595803110 @default.
• W3135509888 cites W2750838281 @default.
• W3135509888 cites W2756305734 @default.
• W3135509888 cites W2756672827 @default.
• W3135509888 cites W2766260318 @default.
• W3135509888 cites W2767569318 @default.
• W3135509888 cites W2771579956 @default.
• W3135509888 cites W2787383605 @default.
• W3135509888 cites W2789457320 @default.
• W3135509888 cites W2794323279 @default.
• W3135509888 cites W2799339598 @default.
• W3135509888 cites W2807772034 @default.
• W3135509888 cites W2811055935 @default.
• W3135509888 cites W2886129647 @default.
• W3135509888 cites W2887366029 @default.
• W3135509888 cites W2888084804 @default.
• W3135509888 cites W2888617722 @default.
• W3135509888 cites W2909790138 @default.
• W3135509888 cites W2911647303 @default.
• W3135509888 cites W2912404417 @default.
• W3135509888 cites W2927290845 @default.

• next