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- W3135537100 abstract "1‐Nitropyrene (1‐NP) is one of the most representative diesel exhaust‐sourced components existing in fine particulate matter (PM2.5) and a potential carcinogen. 1‐NP demonstrates a significant higher cytotoxicity than its structural analogs and precursor. Herein, 1‐NP with its structural analog 3‐nitrofluoranthene and precursor pyrene in human lung epithelial cell lines are compared. An acute reactive oxygen species (ROS) accompanied with cell death is observed for 1‐NP. Using compound‐centric redox proteomics analysis, it is shown that 1‐NP significantly remodeled the redox proteome and specifically targeted on ROS reduction pathway. Superoxide dismutase 1 (SOD1) is identified as a potential target. It is demonstrated that 1‐NP directly acts on cysteine residue Cys111 and inhibits SOD activity. The position of nitroxide determines its direct target and contributes to the unique mechanism of 1‐NP. A novel mechanism for 1‐NP cytotoxicity and ROS induction is therefore proposed." @default.
- W3135537100 created "2021-03-15" @default.
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- W3135537100 date "2021-01-21" @default.
- W3135537100 modified "2023-10-12" @default.
- W3135537100 title "Sulfinylation on Superoxide Dismutase 1 Cys111: Novel Mechanism for 1‐Nitropyrene to Promote Acute Reactive Oxygen Species Generation" @default.
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- W3135537100 doi "https://doi.org/10.1002/sstr.202000123" @default.
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