FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3135548236> ?p ?o ?g. }

• W3135548236 endingPage "2752" @default.
• W3135548236 startingPage "2744" @default.
• W3135548236 abstract "The resolution of inflammation is a biosynthetically active process controlled by the interplay between oxygenated polyunsaturated mediators and G-protein coupled receptor-signaling pathways. These enzymatically oxygenated polyunsaturated fatty acids belong to distinct families of specialized pro-resolving autacoids. The protectin family of mediators has attracted an interest because of their potent pro-resolving and anti-inflammatory actions verified in several in vivo disease models. Herein, we present the stereoselective synthesis and biological evaluations of 3-oxa-PD1n-3 DPA, a protectin D1 analog. Results from mouse models indicate that the mediators protectin D1, PD1n-3 DPA and the new analog 3-oxa-PD1n-3 DPA all relieved streptozotocin-induced diabetic neuropathic pain at doses of 90 and 300 pmol, equivalent to 30 and 100 ng, respectively, following intrathecal (I.T.) injection. Of interest, at a low dose of only 30 pmol (10 ng; I.T.) only 3-oxa PD1n-3 DPA was able to alleviate neuropathic pain, directly compared to vehicle controls. Moreover, using a chronic itch model of cutaneous T-cell lymphoma (CTCL), all three compounds at 300 pmol (100 ng) showed a significant reduction in itching for several hours. The biomolecular information on the structure-functions of the protectins and the new synthetic analog 3-oxa-PD1n-3 DPA is of interest towards developing new immunoresolvents." @default.
• W3135548236 created "2021-03-15" @default.
• W3135548236 creator A5012264077 @default.
• W3135548236 creator A5015333343 @default.
• W3135548236 creator A5029525374 @default.
• W3135548236 creator A5043761078 @default.
• W3135548236 creator A5064427328 @default.
• W3135548236 creator A5082633022 @default.
• W3135548236 date "2021-01-01" @default.
• W3135548236 modified "2023-10-12" @default.
• W3135548236 title "A new synthetic protectin D1 analog 3-oxa-PD1_{n-3 DPA} reduces neuropathic pain and chronic itch in mice" @default.
• W3135548236 cites W1739691545 @default.
• W3135548236 cites W1836416096 @default.
• W3135548236 cites W1883044208 @default.
• W3135548236 cites W1951273690 @default.
• W3135548236 cites W1959056525 @default.
• W3135548236 cites W1967776969 @default.
• W3135548236 cites W1976551390 @default.
• W3135548236 cites W1979477170 @default.
• W3135548236 cites W1982494296 @default.
• W3135548236 cites W1996615849 @default.
• W3135548236 cites W1999682234 @default.
• W3135548236 cites W2003793821 @default.
• W3135548236 cites W2010306979 @default.
• W3135548236 cites W2029004344 @default.
• W3135548236 cites W2046296795 @default.
• W3135548236 cites W2054552572 @default.
• W3135548236 cites W2075715972 @default.
• W3135548236 cites W2076898547 @default.
• W3135548236 cites W2087590528 @default.
• W3135548236 cites W2087868178 @default.
• W3135548236 cites W2090609282 @default.
• W3135548236 cites W2101099639 @default.
• W3135548236 cites W2101182767 @default.
• W3135548236 cites W2103351070 @default.
• W3135548236 cites W2107104127 @default.
• W3135548236 cites W2109070839 @default.
• W3135548236 cites W2110769281 @default.
• W3135548236 cites W2116928239 @default.
• W3135548236 cites W2133476944 @default.
• W3135548236 cites W2141040327 @default.
• W3135548236 cites W2143684129 @default.
• W3135548236 cites W2162465757 @default.
• W3135548236 cites W2169044812 @default.
• W3135548236 cites W2210199222 @default.
• W3135548236 cites W2236135063 @default.
• W3135548236 cites W2300650321 @default.
• W3135548236 cites W2333427125 @default.
• W3135548236 cites W2340209045 @default.
• W3135548236 cites W2512551469 @default.
• W3135548236 cites W2550760233 @default.
• W3135548236 cites W2579756956 @default.
• W3135548236 cites W2602555822 @default.
• W3135548236 cites W2602822324 @default.
• W3135548236 cites W2617279801 @default.
• W3135548236 cites W2623469171 @default.
• W3135548236 cites W2626884794 @default.
• W3135548236 cites W2758648001 @default.
• W3135548236 cites W2771472591 @default.
• W3135548236 cites W2786438865 @default.
• W3135548236 cites W2800441622 @default.
• W3135548236 cites W2801066468 @default.
• W3135548236 cites W2802901067 @default.
• W3135548236 cites W2803887211 @default.
• W3135548236 cites W2883360817 @default.
• W3135548236 cites W2884081766 @default.
• W3135548236 cites W2888968681 @default.
• W3135548236 cites W2896353795 @default.
• W3135548236 cites W2901132121 @default.
• W3135548236 cites W2903575022 @default.
• W3135548236 cites W2980670575 @default.
• W3135548236 cites W3005388406 @default.
• W3135548236 cites W3034203315 @default.
• W3135548236 cites W3042215461 @default.
• W3135548236 cites W3044459192 @default.
• W3135548236 cites W4237669910 @default.
• W3135548236 cites W4253444971 @default.
• W3135548236 doi "https://doi.org/10.1039/d0ob02136a" @default.
• W3135548236 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8016805" @default.
• W3135548236 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33687402" @default.
• W3135548236 hasPublicationYear "2021" @default.
• W3135548236 type Work @default.
• W3135548236 sameAs 3135548236 @default.
• W3135548236 citedByCount "9" @default.
• W3135548236 countsByYear W31355482362021 @default.
• W3135548236 countsByYear W31355482362022 @default.
• W3135548236 countsByYear W31355482362023 @default.
• W3135548236 crossrefType "journal-article" @default.
• W3135548236 hasAuthorship W3135548236A5012264077 @default.
• W3135548236 hasAuthorship W3135548236A5015333343 @default.
• W3135548236 hasAuthorship W3135548236A5029525374 @default.
• W3135548236 hasAuthorship W3135548236A5043761078 @default.
• W3135548236 hasAuthorship W3135548236A5064427328 @default.
• W3135548236 hasAuthorship W3135548236A5082633022 @default.
• W3135548236 hasBestOaLocation W31355482361 @default.
• W3135548236 hasConcept C149588370 @default.
• W3135548236 hasConcept C150903083 @default.
• W3135548236 hasConcept C169760540 @default.

• next