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- W3135565745 abstract "Abstract Doxorubicin (DOX) is a common drug in cancer chemotherapy, and its high DNA-binding affinity can be harnessed in preparing DOX-loaded DNA nanostructures for targeted delivery and therapeutics. Although DOX has been widely studied, the existing literature of DOX-loaded DNA-carriers remains limited and incoherent. Here, based on an in-depth spectroscopic analysis, we characterize and optimize the DOX loading into different 2D and 3D scaffolded DNA origami nanostructures (DONs). In our experimental conditions, all DONs show similar DOX binding capacities (one DOX molecule per two to three base pairs), and the binding equilibrium is reached within seconds, remarkably faster than previously acknowledged. To characterize drug release profiles, DON degradation and DOX release from the complexes upon DNase I digestion was studied. For the employed DONs, the relative doses (DOX molecules released per unit time) may vary by two orders of magnitude depending on the DON superstructure. In addition, we identify DOX aggregation mechanisms and spectral changes linked to pH, magnesium, and DOX concentration. These features have been largely ignored in experimenting with DNA nanostructures, but are probably the major sources of the incoherence of the experimental results so far. Therefore, we believe this work can act as a guide to tailoring the release profiles and developing better drug delivery systems based on DNA-carriers." @default.
- W3135565745 created "2021-03-15" @default.
- W3135565745 creator A5002569955 @default.
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- W3135565745 creator A5076233428 @default.
- W3135565745 date "2021-02-28" @default.
- W3135565745 modified "2023-10-16" @default.
- W3135565745 title "Unraveling the interaction between doxorubicin and DNA origami nanostructures for customizable chemotherapeutic drug release" @default.
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- W3135565745 doi "https://doi.org/10.1093/nar/gkab097" @default.
- W3135565745 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8034656" @default.
- W3135565745 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33660776" @default.
- W3135565745 hasPublicationYear "2021" @default.
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