FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3135620275> ?p ?o ?g. }

• W3135620275 endingPage "2828" @default.
• W3135620275 startingPage "2821" @default.
• W3135620275 abstract "In this study, a catalytic polydopamine-remodeling gold nanoparticle sensitized with an antinucleolin AS1411 probe (pAu nanoprobe) is synthesized, where the surface of the gold nanoparticles (AuNPs) is modified with a spontaneous self-polymerization of a polydopamine coating that imparts the probe functionalization ability and antispecific protein binding while the intrinsic catalytic property of the AuNPs is preserved. The functionalized AS1411 probe exerts specific recognition with nucleolin protein that is found to be overexpressed on the surface of breast cancer cells (MDA-MB-231). Scanning electron microscopy (SEM) confirms that the specific binding of the pAu nanoprobe occurs at the cancer cell surface. Taking advantage of the catalytic ability of the pAu nanoprobe in reducing blue-colored methylene blue (MB) to colorless leuco-MB, a colorimetric biosensing platform is established based on the accessible catalytic active sites on the pAu nanoprobe toward MB. The specific binding inhibits the pAu nanoprobe from efficiently catalyzing the reduction of MB, resulting in a turn-off catalytic biosensing platform. The catalytic conversion of MB is inversely proportional to the concentration of the nucleolin protein and the cancer cells, yielding a detection limit of 15 pM of the nucleolin protein and two cancer cells. The presence of five orders of magnitude higher concentration of bovine serum albumin hardly affects the catalytic ability of the pAu nanoprobe, that is, 88% catalytic ability is still preserved, which validates the specificity of the proposed pAu nanoprobe. In particular, a distinct color contrast creates a significant signal-to-noise ratio so as to enable single-cell level detection of two cancer cells by naked-eye judgment. Moreover, the undiluted, real human serum samples spiked with the cancer cells were examined with an impressive recovery of 94 ± 0.3%, which holds great promise in cancer cell screening." @default.
• W3135620275 created "2021-03-15" @default.
• W3135620275 creator A5003714056 @default.
• W3135620275 creator A5012680130 @default.
• W3135620275 creator A5083349998 @default.
• W3135620275 date "2021-03-01" @default.
• W3135620275 modified "2023-10-08" @default.
• W3135620275 title "Exploiting the Catalytic Ability of Polydopamine-Remodeling Gold Nanoparticles toward the Naked-Eye Detection of Cancer Cells at a Single-Cell Level" @default.
• W3135620275 cites W1548015278 @default.
• W3135620275 cites W1892505945 @default.
• W3135620275 cites W1970478438 @default.
• W3135620275 cites W1971533110 @default.
• W3135620275 cites W1971742328 @default.
• W3135620275 cites W1987337147 @default.
• W3135620275 cites W1995646011 @default.
• W3135620275 cites W2004023680 @default.
• W3135620275 cites W2008779609 @default.
• W3135620275 cites W2022174315 @default.
• W3135620275 cites W2029581320 @default.
• W3135620275 cites W2039658297 @default.
• W3135620275 cites W2041919391 @default.
• W3135620275 cites W2042190518 @default.
• W3135620275 cites W2043915025 @default.
• W3135620275 cites W2067279821 @default.
• W3135620275 cites W2086056107 @default.
• W3135620275 cites W2091482647 @default.
• W3135620275 cites W2092858957 @default.
• W3135620275 cites W2115029038 @default.
• W3135620275 cites W2130389715 @default.
• W3135620275 cites W2234979117 @default.
• W3135620275 cites W2551130236 @default.
• W3135620275 cites W2754446473 @default.
• W3135620275 cites W2765792772 @default.
• W3135620275 cites W2788009719 @default.
• W3135620275 cites W2790042762 @default.
• W3135620275 cites W2888420003 @default.
• W3135620275 cites W2904070633 @default.
• W3135620275 cites W2906912261 @default.
• W3135620275 cites W2910310334 @default.
• W3135620275 cites W2918519574 @default.
• W3135620275 cites W2948005896 @default.
• W3135620275 cites W2965414493 @default.
• W3135620275 cites W2979917481 @default.
• W3135620275 cites W2989306592 @default.
• W3135620275 cites W2993804134 @default.
• W3135620275 cites W3002477579 @default.
• W3135620275 cites W3033456476 @default.
• W3135620275 cites W3049759043 @default.
• W3135620275 doi "https://doi.org/10.1021/acsabm.1c00041" @default.
• W3135620275 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35014321" @default.
• W3135620275 hasPublicationYear "2021" @default.
• W3135620275 type Work @default.
• W3135620275 sameAs 3135620275 @default.
• W3135620275 citedByCount "3" @default.
• W3135620275 countsByYear W31356202752022 @default.
• W3135620275 crossrefType "journal-article" @default.
• W3135620275 hasAuthorship W3135620275A5003714056 @default.
• W3135620275 hasAuthorship W3135620275A5012680130 @default.
• W3135620275 hasAuthorship W3135620275A5083349998 @default.
• W3135620275 hasConcept C104819515 @default.
• W3135620275 hasConcept C119128265 @default.
• W3135620275 hasConcept C12554922 @default.
• W3135620275 hasConcept C128972844 @default.
• W3135620275 hasConcept C153911025 @default.
• W3135620275 hasConcept C155672457 @default.
• W3135620275 hasConcept C160756335 @default.
• W3135620275 hasConcept C161790260 @default.
• W3135620275 hasConcept C16387964 @default.
• W3135620275 hasConcept C171250308 @default.
• W3135620275 hasConcept C183873130 @default.
• W3135620275 hasConcept C185592680 @default.
• W3135620275 hasConcept C190062978 @default.
• W3135620275 hasConcept C192562407 @default.
• W3135620275 hasConcept C2776525860 @default.
• W3135620275 hasConcept C2779191827 @default.
• W3135620275 hasConcept C43617362 @default.
• W3135620275 hasConcept C55493867 @default.
• W3135620275 hasConcept C65165184 @default.
• W3135620275 hasConcept C86803240 @default.
• W3135620275 hasConceptScore W3135620275C104819515 @default.
• W3135620275 hasConceptScore W3135620275C119128265 @default.
• W3135620275 hasConceptScore W3135620275C12554922 @default.
• W3135620275 hasConceptScore W3135620275C128972844 @default.
• W3135620275 hasConceptScore W3135620275C153911025 @default.
• W3135620275 hasConceptScore W3135620275C155672457 @default.
• W3135620275 hasConceptScore W3135620275C160756335 @default.
• W3135620275 hasConceptScore W3135620275C161790260 @default.
• W3135620275 hasConceptScore W3135620275C16387964 @default.
• W3135620275 hasConceptScore W3135620275C171250308 @default.
• W3135620275 hasConceptScore W3135620275C183873130 @default.
• W3135620275 hasConceptScore W3135620275C185592680 @default.
• W3135620275 hasConceptScore W3135620275C190062978 @default.
• W3135620275 hasConceptScore W3135620275C192562407 @default.
• W3135620275 hasConceptScore W3135620275C2776525860 @default.
• W3135620275 hasConceptScore W3135620275C2779191827 @default.
• W3135620275 hasConceptScore W3135620275C43617362 @default.
• W3135620275 hasConceptScore W3135620275C55493867 @default.
• W3135620275 hasConceptScore W3135620275C65165184 @default.

• next