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• W3135631337 abstract "3-nitropropionic acid (3-NP) is a toxin that causes neural damage in the striatum and can lead to the development of Huntington's disease manifestations in animal models. Several studies have shown genotoxicity related to the 3-NP treatment. This study investigated potential genotoxicity and mutagenicity that was induced by a low dose (6.25 mg/kg i. p.) 3-NP subacute treatment (daily, over 6 days) in a rat model. The arterial blood and the frontal cortex were analyzed by the comet assay and the bone marrow by micronucleus. Surprisingly, the 3-NP subacute treatment with the low dose did not show genotoxic or mutagenic effects." @default.
• W3135631337 created "2021-03-15" @default.
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• W3135631337 date "2021-05-01" @default.
• W3135631337 modified "2023-09-26" @default.
• W3135631337 title "In vivo treatment with a subacute low dose of 3-nitropropionic acid does not induce genotoxicity or mutagenicity in rats" @default.
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• W3135631337 doi "https://doi.org/10.1016/j.toxicon.2021.03.001" @default.
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