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• W3135636997 abstract "Xanthones (9H-xanthene-9-ones) are considered to be very promising compounds due to a variety of interesting biological and pharmacological activities. In this study, column chromatography of the methanol extract of the Garcinia mangostana L. pericarps resulted in the isolation of four new xanthones (garcinoxanthones SV, 1–4) and five known analogs including garcinone E (5), 11-hydroxy-1-isomangostin (6) mangostenone E (7), 1,3,6,7-tetrahydroxyxanthone (8), and α-mangostin (9). The structures of the new compounds were elucidated by NMR, HRESIMS, and ECD spectra. Compound 8 (1,3,6,7-tetrahydroxyxanthone) was found from the G. mangostana pericarps for the first time. All the isolated compounds (1–8) were evaluated for their 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging capacity and cytotoxicity in vitro against three human cancer cell lines including SK-LU-1, MCF7, and HT-29 cell lines. Compounds 3, 5, and 8 exhibited significant DPPH scavenging capacity with IC50 values of 68.55, 63.05, and 28.45 μM, respectively, in comparison with ascorbic acid (IC50 = 48.03 μM). Compounds 5 and 8 showed moderate cytotoxic effects against the three human cancer cell lines with IC50 value ranges of 19.86–27.38 μM." @default.
• W3135636997 created "2021-03-15" @default.
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• W3135636997 date "2021-06-01" @default.
• W3135636997 modified "2023-09-22" @default.
• W3135636997 title "Garcinoxanthones S V, new xanthone derivatives from the pericarps of Garcinia mangostana together with their cytotoxic and antioxidant activities" @default.
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• W3135636997 doi "https://doi.org/10.1016/j.fitote.2021.104880" @default.
• W3135636997 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33711431" @default.
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