Matches in SemOpenAlex for { <https://semopenalex.org/work/W3135644338> ?p ?o ?g. }
- W3135644338 abstract "The sites of targeted therapy are limited and need to be expanded. The FGF-FGFR signalling plays pivotal roles in the oncogenic process, and FGF/FGFR inhibitors are a promising method to treat FGFR-altered tumours. The VEGF-VEGFR signalling is the most crucial pathway to induce angiogenesis, and inhibiting this cascade has already got success in treating tumours. While both their efficacy and antitumour spectrum are limited, combining FGF/FGFR inhibitors with VEGF/VEGFR inhibitors are an excellent way to optimize the curative effect and expand the antitumour range because their combination can target both tumour cells and the tumour microenvironment. In addition, biomarkers need to be developed to predict the efficacy, and combination with immune checkpoint inhibitors is a promising direction in the future. The article will discuss the FGF-FGFR signalling pathway, the VEGF-VEGFR signalling pathway, the rationale of combining these two signalling pathways and recent small-molecule FGFR/VEGFR inhibitors based on clinical trials." @default.
- W3135644338 created "2021-03-15" @default.
- W3135644338 creator A5006882159 @default.
- W3135644338 creator A5024818901 @default.
- W3135644338 creator A5037987990 @default.
- W3135644338 creator A5080774369 @default.
- W3135644338 creator A5090403310 @default.
- W3135644338 date "2021-03-02" @default.
- W3135644338 modified "2023-10-12" @default.
- W3135644338 title "Inhibition of FGF‐FGFR and VEGF‐VEGFR signalling in cancer treatment" @default.
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