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- W3135650345 endingPage "2004068" @default.
- W3135650345 startingPage "2004068" @default.
- W3135650345 abstract "Resealing of membrane pores is crucial for cell survival. Membrane surface charge and medium composition are studied as defining regulators of membrane stability. Pores are generated by electric field or detergents. Giant vesicles composed of zwitterionic and negatively charged lipids mixed at varying ratios are subjected to a strong electric pulse. Interestingly, charged vesicles appear prone to catastrophic collapse transforming them into tubular structures. The spectrum of destabilization responses includes the generation of long-living submicroscopic pores and partial vesicle bursting. The origin of these phenomena is related to the membrane edge tension, which governs pore closure. This edge tension significantly decreases as a function of the fraction of charged lipids. Destabilization of charged vesicles upon pore formation is universal-it is also observed with other poration stimuli. Disruption propensity is enhanced for membranes made of lipids with higher degree of unsaturation. It can be reversed by screening membrane charge in the presence of calcium ions. The observed findings in light of theories of stability and curvature generation are interpreted and mechanisms acting in cells to prevent total membrane collapse upon poration are discussed. Enhanced membrane stability is crucial for the success of electroporation-based technologies for cancer treatment and gene transfer." @default.
- W3135650345 created "2021-03-15" @default.
- W3135650345 creator A5004743497 @default.
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- W3135650345 creator A5041538469 @default.
- W3135650345 creator A5057944337 @default.
- W3135650345 creator A5071086704 @default.
- W3135650345 date "2021-03-08" @default.
- W3135650345 modified "2023-10-01" @default.
- W3135650345 title "To Close or to Collapse: The Role of Charges on Membrane Stability upon Pore Formation" @default.
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