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- W3135655283 abstract "A sequence of pyrazole hydrazides (8a-8r) was synthesized (E)-N-(5-(2-(2-(4-methoxy-2,3-dimethylbenzylidene) hydrazinyl)-2-oxoethyl)-1H-pyrazol-3-yl)-3-(trifluoromethyl) benzamide (8a), and its anti-microbial activities were studied for its in vitro anti-microbial activities against staphylococcus aureus and Escherichia coli and found almost all synthesized molecules are active. Also synthesized molecules were ascertained by 1H NMR, 13C NMR and mass spectroscopy pyrazole hydrazides was synthesized by dehydration reaction of 2-(3-(5-bromo-2-fluorobenzamido)-1H-pyrazol-5-yl) acetohydrazide (7) with different aldehydes. All the reaction progress were monitored by TLC. Minimum inhibition values of synthesized molecules were studied using Staphylococcus aureus and Escherichia coli and found some of the compounds show good MIC values such as 8 g (24), 8j (23), 8 k (23) as compared to existing drug cefotaxime." @default.
- W3135655283 created "2021-03-15" @default.
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- W3135655283 date "2021-01-01" @default.
- W3135655283 modified "2023-09-27" @default.
- W3135655283 title "Synthesis and biological evaluations of new pyrazole hydrazides as potent anti-microbial agent" @default.
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- W3135655283 doi "https://doi.org/10.1016/j.matpr.2021.02.024" @default.
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