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- W3135655585 abstract "Abstract There is growing evidence that mutations in non-coding cis -regulatory elements (CREs) disrupt proper development. However, little is known about human CREs that are crucial for cardiovascular development. To address this, we bioinformatically identified cardiovascular CREs based on the occupancy of the CRE by the homeodomain protein NKX2-5 and cardiac chromatin histone modifications. This search defined a highly conserved CRE within the FLT1 locus termed enFLT1 . We show that the human enFLT1 is an enhancer capable of driving reporter transgene expression in vivo throughout the developing cardiovascular system of medaka. Deletion of the human enFLT1 enhancer ( ΔenFLT1 ) triggered molecular perturbations in extracellular matrix organisation and blood vessel morphogenesis in vitro in endothelial cells derived from human embryonic stem cells and vascular defects in vivo in medaka. These findings highlight the crucial role of the human FLT1 enhancer and its function as a regulator and buffer of transcriptional regulation in cardiovascular development." @default.
- W3135655585 created "2021-03-15" @default.
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- W3135655585 date "2021-03-06" @default.
- W3135655585 modified "2023-10-10" @default.
- W3135655585 title "The human<i>FLT1</i>regulatory element directs vascular expression and modulates angiogenesis pathways<i>in vitro</i>and<i>in vivo</i>" @default.
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- W3135655585 doi "https://doi.org/10.1101/2021.03.03.433738" @default.
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