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• W3135673958 abstract "The loss of dopamine (DA)-producing neurons in the substantia nigra pars compacta (SN) underlies the core motor symptoms of the progressive movement disorder Parkinson's disease (PD). To date, no treatment to prevent or slow SN DA neurodegeneration exists; thus, the identification of the underlying factors contributing to the high vulnerability of these neurons represents the basis for the development of novel therapies. Disrupted Ca 2+ homeostasis and mitochondrial dysfunction seem to be key players in the pathophysiology of PD. The autonomous pacemaker activity of SN DA neurons, in combination with low cytosolic Ca 2+ buffering, leads to large somatodendritic fluctuations of intracellular Ca 2+ levels that are linked to elevated mitochondrial oxidant stress. L-type voltage-gated Ca 2+ channels (LTCCs) contribute to these Ca 2+ oscillations in dendrites, and LTCC inhibition was beneficial in cellular and in vivo animal models of PD. However, in a recently completed phase 3 clinical trial, the dihydropyridine (DHP) LTCC inhibitor isradipine failed to slow disease progression in early PD patients, questioning the feasibility of DHPs for PD therapy. Novel evidence also suggests that R- and T-type Ca 2+ channels (RTCCs and TTCCs, respectively) represent potential PD drug targets. This short review aims to (re)evaluate the therapeutic potential of LTCC, RTCC, and TTCC inhibition in light of novel preclinical and clinical data and the feasibility of available Ca 2+ channel blockers to modify PD disease progression. I also summarize their cell-specific roles for SN DA neuron function and describe how their gating properties allow activity (and thus their contribution to stressful Ca 2+ oscillations) during pacemaking." @default.
• W3135673958 created "2021-03-15" @default.
• W3135673958 creator A5042631052 @default.
• W3135673958 date "2021-02-26" @default.
• W3135673958 modified "2023-10-01" @default.
• W3135673958 title "Voltage-Gated Ca2+ Channels in Dopaminergic Substantia Nigra Neurons: Therapeutic Targets for Neuroprotection in Parkinson's Disease?" @default.
• W3135673958 cites W1510439895 @default.
• W3135673958 cites W1601244397 @default.
• W3135673958 cites W1633847368 @default.
• W3135673958 cites W1886354815 @default.
• W3135673958 cites W1921440755 @default.
• W3135673958 cites W1949404224 @default.
• W3135673958 cites W1964092556 @default.
• W3135673958 cites W1967622946 @default.
• W3135673958 cites W1970222424 @default.
• W3135673958 cites W1981745072 @default.
• W3135673958 cites W1981791591 @default.
• W3135673958 cites W1981896177 @default.
• W3135673958 cites W1983267597 @default.
• W3135673958 cites W1985069323 @default.
• W3135673958 cites W1988760320 @default.
• W3135673958 cites W1993422093 @default.
• W3135673958 cites W199354732 @default.
• W3135673958 cites W1995037276 @default.
• W3135673958 cites W1997424855 @default.
• W3135673958 cites W1998242611 @default.
• W3135673958 cites W2002474522 @default.
• W3135673958 cites W2003145203 @default.
• W3135673958 cites W2006200262 @default.
• W3135673958 cites W2008933728 @default.
• W3135673958 cites W2010680034 @default.
• W3135673958 cites W2013503732 @default.
• W3135673958 cites W2016519468 @default.
• W3135673958 cites W2018587726 @default.
• W3135673958 cites W2020552145 @default.
• W3135673958 cites W2021272772 @default.
• W3135673958 cites W2032781518 @default.
• W3135673958 cites W2034497865 @default.
• W3135673958 cites W2036111495 @default.
• W3135673958 cites W2048484812 @default.
• W3135673958 cites W2057198039 @default.
• W3135673958 cites W2061220110 @default.
• W3135673958 cites W2063801257 @default.
• W3135673958 cites W2065008766 @default.
• W3135673958 cites W2067174160 @default.
• W3135673958 cites W2077932410 @default.
• W3135673958 cites W2079286959 @default.
• W3135673958 cites W2081685281 @default.
• W3135673958 cites W2082438131 @default.
• W3135673958 cites W2084650733 @default.
• W3135673958 cites W2084657878 @default.
• W3135673958 cites W2085006562 @default.
• W3135673958 cites W2087866577 @default.
• W3135673958 cites W2090020119 @default.
• W3135673958 cites W2095836715 @default.
• W3135673958 cites W2095897702 @default.
• W3135673958 cites W2096701787 @default.
• W3135673958 cites W2105752313 @default.
• W3135673958 cites W2115791394 @default.
• W3135673958 cites W2116739536 @default.
• W3135673958 cites W2120935292 @default.
• W3135673958 cites W2121520642 @default.
• W3135673958 cites W2131991755 @default.
• W3135673958 cites W2139233019 @default.
• W3135673958 cites W2147381068 @default.
• W3135673958 cites W2154905702 @default.
• W3135673958 cites W2155735267 @default.
• W3135673958 cites W2165126772 @default.
• W3135673958 cites W2168057727 @default.
• W3135673958 cites W2168126136 @default.
• W3135673958 cites W2171601942 @default.
• W3135673958 cites W2200183975 @default.
• W3135673958 cites W2280506293 @default.
• W3135673958 cites W2411729015 @default.
• W3135673958 cites W2413295084 @default.
• W3135673958 cites W2417443854 @default.
• W3135673958 cites W2465115919 @default.
• W3135673958 cites W2470770608 @default.
• W3135673958 cites W2491603413 @default.
• W3135673958 cites W2513552499 @default.
• W3135673958 cites W2515048964 @default.
• W3135673958 cites W2571740089 @default.
• W3135673958 cites W2572639738 @default.
• W3135673958 cites W2577617665 @default.
• W3135673958 cites W2593303242 @default.
• W3135673958 cites W2610315419 @default.
• W3135673958 cites W2611890509 @default.
• W3135673958 cites W2614083744 @default.
• W3135673958 cites W2623805123 @default.
• W3135673958 cites W2741297747 @default.
• W3135673958 cites W2753051298 @default.
• W3135673958 cites W2769091649 @default.
• W3135673958 cites W2788764523 @default.
• W3135673958 cites W2792953109 @default.
• W3135673958 cites W2796389302 @default.
• W3135673958 cites W2802883744 @default.
• W3135673958 cites W2892337763 @default.
• W3135673958 cites W2896586855 @default.
• W3135673958 cites W2909287823 @default.
• W3135673958 cites W2910008477 @default.

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