Matches in SemOpenAlex for { <https://semopenalex.org/work/W3135705814> ?p ?o ?g. }
- W3135705814 endingPage "369" @default.
- W3135705814 startingPage "351" @default.
- W3135705814 abstract "Lung cancer continues to be the number one cancer killer. Despite a surge of therapeutic advances in recent years, lung cancer remains fatal when it presents at a stage too advanced for surgical resection. In part, this is due to the disappointing reality of inevitable drug resistance in the face of highly effective, mutation-specific chemotherapy and the limited efficacy of immune checkpoint blockade. Yet, with the increasing application and integration of diverse genomic profiling approaches and the advent of high-content single-cell technologies, the mechanisms of lung cancer initiation, evolution, spread, and resistance are being unraveled at unprecedented resolution. Increasingly sophisticated mouse genetic, xenotransplantation, and ex vivo assays are also enabling functional validation and empiric screening of new therapeutic candidates. In this review, I highlight recent insights into the genetic, cellular, and molecular mechanisms of lung cancer and relate them to the normal biology of the developing and mature lung." @default.
- W3135705814 created "2021-03-15" @default.
- W3135705814 creator A5071885288 @default.
- W3135705814 date "2021-03-04" @default.
- W3135705814 modified "2023-10-11" @default.
- W3135705814 title "Developmental Insights into Lung Cancer" @default.
- W3135705814 cites W1611210979 @default.
- W3135705814 cites W1648092828 @default.
- W3135705814 cites W1872124794 @default.
- W3135705814 cites W1969837517 @default.
- W3135705814 cites W1970982374 @default.
- W3135705814 cites W1976088762 @default.
- W3135705814 cites W1978893674 @default.
- W3135705814 cites W1980533832 @default.
- W3135705814 cites W1980544777 @default.
- W3135705814 cites W2025262845 @default.
- W3135705814 cites W2032430075 @default.
- W3135705814 cites W2045729702 @default.
- W3135705814 cites W2049674541 @default.
- W3135705814 cites W2068881679 @default.
- W3135705814 cites W2077297619 @default.
- W3135705814 cites W2086239585 @default.
- W3135705814 cites W2098845541 @default.
- W3135705814 cites W2112795260 @default.
- W3135705814 cites W2116926981 @default.
- W3135705814 cites W2138549950 @default.
- W3135705814 cites W2145411470 @default.
- W3135705814 cites W2303309927 @default.
- W3135705814 cites W2461903592 @default.
- W3135705814 cites W2513280988 @default.
- W3135705814 cites W2519953954 @default.
- W3135705814 cites W2529655703 @default.
- W3135705814 cites W2531194180 @default.
- W3135705814 cites W2538658987 @default.
- W3135705814 cites W2583044716 @default.
- W3135705814 cites W2584487585 @default.
- W3135705814 cites W2590140826 @default.
- W3135705814 cites W2590146273 @default.
- W3135705814 cites W2599492201 @default.
- W3135705814 cites W2602918448 @default.
- W3135705814 cites W2604498317 @default.
- W3135705814 cites W2609243345 @default.
- W3135705814 cites W2611596972 @default.
- W3135705814 cites W2612504410 @default.
- W3135705814 cites W2612786119 @default.
- W3135705814 cites W2613058366 @default.
- W3135705814 cites W2625859437 @default.
- W3135705814 cites W2691615730 @default.
- W3135705814 cites W2730322366 @default.
- W3135705814 cites W2739473960 @default.
- W3135705814 cites W2750254726 @default.
- W3135705814 cites W2756111880 @default.
- W3135705814 cites W2766883747 @default.
- W3135705814 cites W2767162493 @default.
- W3135705814 cites W2768205654 @default.
- W3135705814 cites W2772812510 @default.
- W3135705814 cites W2774267942 @default.
- W3135705814 cites W2779316498 @default.
- W3135705814 cites W2783397995 @default.
- W3135705814 cites W2783441930 @default.
- W3135705814 cites W2785809325 @default.
- W3135705814 cites W2786421413 @default.
- W3135705814 cites W2786576080 @default.
- W3135705814 cites W2786613800 @default.
- W3135705814 cites W2788439692 @default.
- W3135705814 cites W2788630243 @default.
- W3135705814 cites W2791241097 @default.
- W3135705814 cites W2792828274 @default.
- W3135705814 cites W2794280940 @default.
- W3135705814 cites W2794820058 @default.
- W3135705814 cites W2795125292 @default.
- W3135705814 cites W2795258573 @default.
- W3135705814 cites W2795842108 @default.
- W3135705814 cites W2796153844 @default.
- W3135705814 cites W2796183066 @default.
- W3135705814 cites W2797675588 @default.
- W3135705814 cites W2797855256 @default.
- W3135705814 cites W2800502929 @default.
- W3135705814 cites W2803328077 @default.
- W3135705814 cites W2805421814 @default.
- W3135705814 cites W2807032285 @default.
- W3135705814 cites W2808837841 @default.
- W3135705814 cites W2810630532 @default.
- W3135705814 cites W2865352686 @default.
- W3135705814 cites W2888532347 @default.
- W3135705814 cites W2890618054 @default.
- W3135705814 cites W2895058922 @default.
- W3135705814 cites W2895496651 @default.
- W3135705814 cites W2895908547 @default.
- W3135705814 cites W2898215009 @default.
- W3135705814 cites W2898288153 @default.
- W3135705814 cites W2899311685 @default.
- W3135705814 cites W2900850487 @default.
- W3135705814 cites W2902872573 @default.
- W3135705814 cites W2904734418 @default.
- W3135705814 cites W2905529840 @default.
- W3135705814 cites W2910248442 @default.
- W3135705814 cites W2912060875 @default.