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- W3135734893 abstract "Background: Nabiximols oromucosal spray (Sativex ® ) is an approved add-on treatment option for moderate-to-severe treatment-resistant multiple sclerosis (MS) spasticity. Materials & methods: This prospective, observational, noninterventional, 3-month follow-up pilot study assessed the evolution of patient-selected goal attainment scale (GAS) item scores and of MS spasticity and associated symptoms during nabiximols treatment. Results: In the full analysis set (n = 21), the mean (SD) overall unweighted GAS score increased from 32.1 (3.4) at baseline to 43.6 (14.6) at month 3 (p = 0.0060), constituting a clinically meaningful change. Slight improvements were observed in MS spasticity and most associated symptoms. Nabiximols improved walking ability and was well tolerated. Conclusion: The study provides proof-of-concept that GAS methodology can be applied to MS management in daily practice." @default.
- W3135734893 created "2021-03-15" @default.
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- W3135734893 date "2021-04-01" @default.
- W3135734893 modified "2023-10-16" @default.
- W3135734893 title "Effect of nabiximols on Goal Attainment Scale scores in patients with treatment-resistant multiple sclerosis spasticity" @default.
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- W3135734893 doi "https://doi.org/10.2217/nmt-2020-0060" @default.
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