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- W3135743555 endingPage "517" @default.
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- W3135743555 abstract "GABAA receptors are pentameric ligand-gated ion channels that mediate most fast neuronal inhibition in the brain. In addition to their important physiological roles, they are noteworthy in their rich pharmacology; prominent drugs used for anxiety, insomnia, and general anesthesia act through positive modulation of GABAA receptors. Direct structural information for how these drugs work was absent until recently. Efforts in structural biology over the past few years have revealed how important drug classes and natural products interact with the GABAA receptor, providing a foundation for studies in dynamics and structure-guided drug design. Here, we review recent developments in GABAA receptor structural pharmacology, focusing on subunit assemblies of the receptor found at synapses." @default.
- W3135743555 created "2021-03-15" @default.
- W3135743555 creator A5024787740 @default.
- W3135743555 creator A5062277314 @default.
- W3135743555 date "2021-06-01" @default.
- W3135743555 modified "2023-09-29" @default.
- W3135743555 title "Direct Structural Insights into GABAA Receptor Pharmacology" @default.
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