FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3135745900> ?p ?o ?g. }

• W3135745900 endingPage "859" @default.
• W3135745900 startingPage "847" @default.
• W3135745900 abstract "The popularity of botanical and other purported medicinal natural products (NPs) continues to grow, especially among patients with chronic illnesses and patients managed on complex prescription drug regimens. With few exceptions, the risk of a given NP to precipitate a clinically significant pharmacokinetic NP-drug interaction (NPDI) remains understudied or unknown. Application of static or dynamic mathematical models to predict and/or simulate NPDIs can provide critical information about the potential clinical significance of these complex interactions. However, methods used to conduct such predictions or simulations are highly variable. Additionally, published reports using mathematical models to interrogate NPDIs are not always sufficiently detailed to ensure reproducibility. Consequently, guidelines are needed to inform the conduct and reporting of these modeling efforts. This recommended approach from the Center of Excellence for Natural Product Drug Interaction Research describes a systematic method for using mathematical models to interpret the interaction risk of NPs as precipitants of potential clinically significant pharmacokinetic NPDIs. A framework for developing and applying pharmacokinetic NPDI models is presented with the aim of promoting accuracy, reproducibility, and generalizability in the literature. SIGNIFICANCE STATEMENT: Many natural products (NPs) contain phytoconstituents that can increase or decrease systemic or tissue exposure to, and potentially the efficacy of, a pharmaceutical drug; however, no regulatory agency guidelines exist to assist in predicting the risk of these complex interactions. This recommended approach from a multi-institutional consortium designated by National Institutes of Health as the Center of Excellence for Natural Product Drug Interaction Research provides a framework for modeling pharmacokinetic NP-drug interactions." @default.
• W3135745900 created "2021-03-15" @default.
• W3135745900 creator A5004489015 @default.
• W3135745900 creator A5020600016 @default.
• W3135745900 creator A5024123937 @default.
• W3135745900 creator A5038495851 @default.
• W3135745900 creator A5045793546 @default.
• W3135745900 creator A5066900523 @default.
• W3135745900 creator A5080624375 @default.
• W3135745900 creator A5083433629 @default.
• W3135745900 date "2021-03-12" @default.
• W3135745900 modified "2023-10-12" @default.
• W3135745900 title "Modeling Pharmacokinetic Natural Product–Drug Interactions for Decision-Making: A NaPDI Center Recommended Approach" @default.
• W3135745900 cites W1520583260 @default.
• W3135745900 cites W1548404106 @default.
• W3135745900 cites W1584158990 @default.
• W3135745900 cites W1608678137 @default.
• W3135745900 cites W1752026660 @default.
• W3135745900 cites W1850593534 @default.
• W3135745900 cites W1895993106 @default.
• W3135745900 cites W1963543020 @default.
• W3135745900 cites W1972441328 @default.
• W3135745900 cites W1978681800 @default.
• W3135745900 cites W1980685532 @default.
• W3135745900 cites W1985106325 @default.
• W3135745900 cites W1985232876 @default.
• W3135745900 cites W1986182628 @default.
• W3135745900 cites W1986373841 @default.
• W3135745900 cites W2010448327 @default.
• W3135745900 cites W2013697678 @default.
• W3135745900 cites W2024012503 @default.
• W3135745900 cites W2027243036 @default.
• W3135745900 cites W2037705821 @default.
• W3135745900 cites W2051167812 @default.
• W3135745900 cites W2053138932 @default.
• W3135745900 cites W2057459363 @default.
• W3135745900 cites W2060917067 @default.
• W3135745900 cites W2074810960 @default.
• W3135745900 cites W2092661856 @default.
• W3135745900 cites W2098449081 @default.
• W3135745900 cites W2103333792 @default.
• W3135745900 cites W2103606212 @default.
• W3135745900 cites W2108458189 @default.
• W3135745900 cites W2111034418 @default.
• W3135745900 cites W2117170820 @default.
• W3135745900 cites W2136191240 @default.
• W3135745900 cites W2139290108 @default.
• W3135745900 cites W2142898360 @default.
• W3135745900 cites W2144190030 @default.
• W3135745900 cites W2144465276 @default.
• W3135745900 cites W2155590214 @default.
• W3135745900 cites W2161461118 @default.
• W3135745900 cites W2171482501 @default.
• W3135745900 cites W2261989129 @default.
• W3135745900 cites W2264413336 @default.
• W3135745900 cites W2266055629 @default.
• W3135745900 cites W2346462946 @default.
• W3135745900 cites W2517182458 @default.
• W3135745900 cites W2522795135 @default.
• W3135745900 cites W2566511345 @default.
• W3135745900 cites W2592877666 @default.
• W3135745900 cites W2622068805 @default.
• W3135745900 cites W2757788011 @default.
• W3135745900 cites W2765833669 @default.
• W3135745900 cites W2775780124 @default.
• W3135745900 cites W2789395859 @default.
• W3135745900 cites W2790648044 @default.
• W3135745900 cites W2793955767 @default.
• W3135745900 cites W2794194106 @default.
• W3135745900 cites W2799793961 @default.
• W3135745900 cites W2802912539 @default.
• W3135745900 cites W2804552830 @default.
• W3135745900 cites W2883269759 @default.
• W3135745900 cites W2884014374 @default.
• W3135745900 cites W2887655204 @default.
• W3135745900 cites W2888204619 @default.
• W3135745900 cites W2889241014 @default.
• W3135745900 cites W2894151357 @default.
• W3135745900 cites W2896835015 @default.
• W3135745900 cites W2902341473 @default.
• W3135745900 cites W2909327207 @default.
• W3135745900 cites W2909520649 @default.
• W3135745900 cites W2912186899 @default.
• W3135745900 cites W2913456570 @default.
• W3135745900 cites W2914000229 @default.
• W3135745900 cites W2925298688 @default.
• W3135745900 cites W2944476630 @default.
• W3135745900 cites W2947444149 @default.
• W3135745900 cites W2950173838 @default.
• W3135745900 cites W2950539609 @default.
• W3135745900 cites W2996402632 @default.
• W3135745900 cites W2999902773 @default.
• W3135745900 cites W3004261029 @default.
• W3135745900 cites W3014361541 @default.
• W3135745900 cites W3034310684 @default.
• W3135745900 cites W3038075533 @default.
• W3135745900 cites W3038080063 @default.
• W3135745900 cites W3044700332 @default.

• next