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- W3135748605 abstract "Aims & Objectives: Posterior reversible encephalopathy syndrome (PRES) syndrome is classically a reversible syndrome defined by presence of headache, altered mental status (AMS), seizures, and visual changes associated with predominantly posterior leukoencephalopathy on imaging. First described in adults in 1996, there is now growing literature describing more atypical features in children. Methods: Retrospective chart review of all children diagnosed with PRES from 2010 to 2018 at a quaternary children’s hospital. Results: 18 patients(1-18 years old, 61% female). All had seizures and AMS. 27.8% had vision changes. BP percentiles were ≥99%ile for all patients. 27% had renal disease, 33.3% preexisting organ transplants, 55% immunosuppressed, 11.1% autoimmune disease, 11.1% eclampsia, 22.3% with suspected infectious causes, and 23.1% with oncologic processes. Focal neurologic exam findings noted in 50%. All with abnormal magnetic resonance imaging (MRI). MRI in 77.8% described as “atypical.” Prior pediatric case studies had suggested risk factors of anemia, hypomagnesemia and hypocalcemia. In our cohort, 66.7% were anemic, 11.1% hypomagnesemic and 22.2% hypocalcemic.Conclusions: Pediatric PRES is closely associated with hypertension and chronic disease, however in our cohort 22% of patients were not chronically ill. These patients will not universally be on cytotoxic medications but will present almost universally with seizures and encephalopathy, most typically in the setting of hypertension. Children may also present with focal neurologic deficits, further differing from adults. The MRI findings are more often atypical, and anemia continues to appear to be an independent risk factor. We suggest that a diagnosis of PRES be considered for children presenting with hypertension, seizures and encephalopathy." @default.
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- W3135748605 date "2021-03-01" @default.
- W3135748605 modified "2023-10-16" @default.
- W3135748605 title "P0013 / #798: WHAT IS TYPICAL PEDIATRIC POSTERIOR REVERSIBLE ENCEPHALOPATHY SYNDROME?" @default.
- W3135748605 doi "https://doi.org/10.1097/01.pcc.0000738396.26743.47" @default.
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