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• W3135750489 abstract "Background & AimsGiven that gastrointestinal (GI) symptoms are a prominent extrapulmonary manifestation of COVID-19, we investigated intestinal infection with SARS-CoV-2, its effect on pathogenesis, and clinical significance.MethodsHuman intestinal biopsy tissues were obtained from patients with COVID-19 (n = 19) and uninfected control individuals (n = 10) for microscopic examination, cytometry by time of flight analyses, and RNA sequencing. Additionally, disease severity and mortality were examined in patients with and without GI symptoms in 2 large, independent cohorts of hospitalized patients in the United States (N = 634) and Europe (N = 287) using multivariate logistic regressions.ResultsCOVID-19 case patients and control individuals in the biopsy cohort were comparable for age, sex, rates of hospitalization, and relevant comorbid conditions. SARS-CoV-2 was detected in small intestinal epithelial cells by immunofluorescence staining or electron microscopy in 15 of 17 patients studied. High-dimensional analyses of GI tissues showed low levels of inflammation, including down-regulation of key inflammatory genes including IFNG, CXCL8, CXCL2, and IL1B and reduced frequencies of proinflammatory dendritic cells compared with control individuals. Consistent with these findings, we found a significant reduction in disease severity and mortality in patients presenting with GI symptoms that was independent of sex, age, and comorbid illnesses and despite similar nasopharyngeal SARS-CoV-2 viral loads. Furthermore, there was reduced levels of key inflammatory proteins in circulation in patients with GI symptoms.ConclusionsThese data highlight the absence of a proinflammatory response in the GI tract despite detection of SARS-CoV-2. In parallel, reduced mortality in patients with COVID-19 presenting with GI symptoms was observed. A potential role of the GI tract in attenuating SARS-CoV-2–associated inflammation needs to be further examined. Given that gastrointestinal (GI) symptoms are a prominent extrapulmonary manifestation of COVID-19, we investigated intestinal infection with SARS-CoV-2, its effect on pathogenesis, and clinical significance. Human intestinal biopsy tissues were obtained from patients with COVID-19 (n = 19) and uninfected control individuals (n = 10) for microscopic examination, cytometry by time of flight analyses, and RNA sequencing. Additionally, disease severity and mortality were examined in patients with and without GI symptoms in 2 large, independent cohorts of hospitalized patients in the United States (N = 634) and Europe (N = 287) using multivariate logistic regressions. COVID-19 case patients and control individuals in the biopsy cohort were comparable for age, sex, rates of hospitalization, and relevant comorbid conditions. SARS-CoV-2 was detected in small intestinal epithelial cells by immunofluorescence staining or electron microscopy in 15 of 17 patients studied. High-dimensional analyses of GI tissues showed low levels of inflammation, including down-regulation of key inflammatory genes including IFNG, CXCL8, CXCL2, and IL1B and reduced frequencies of proinflammatory dendritic cells compared with control individuals. Consistent with these findings, we found a significant reduction in disease severity and mortality in patients presenting with GI symptoms that was independent of sex, age, and comorbid illnesses and despite similar nasopharyngeal SARS-CoV-2 viral loads. Furthermore, there was reduced levels of key inflammatory proteins in circulation in patients with GI symptoms. These data highlight the absence of a proinflammatory response in the GI tract despite detection of SARS-CoV-2. In parallel, reduced mortality in patients with COVID-19 presenting with GI symptoms was observed. A potential role of the GI tract in attenuating SARS-CoV-2–associated inflammation needs to be further examined." @default.
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• W3135750489 date "2021-06-01" @default.
• W3135750489 modified "2023-10-18" @default.
• W3135750489 title "Intestinal Host Response to SARS-CoV-2 Infection and COVID-19 Outcomes in Patients With Gastrointestinal Symptoms" @default.
• W3135750489 cites W1532774876 @default.
• W3135750489 cites W1757215199 @default.
• W3135750489 cites W1982189917 @default.
• W3135750489 cites W1994844769 @default.
• W3135750489 cites W1999574084 @default.
• W3135750489 cites W2003394211 @default.
• W3135750489 cites W2045356950 @default.
• W3135750489 cites W2094869832 @default.
• W3135750489 cites W2097702986 @default.
• W3135750489 cites W2099540110 @default.
• W3135750489 cites W2107018762 @default.
• W3135750489 cites W2114104545 @default.
• W3135750489 cites W2114361018 @default.
• W3135750489 cites W2115462905 @default.
• W3135750489 cites W2124954099 @default.
• W3135750489 cites W2130410032 @default.
• W3135750489 cites W2132780101 @default.
• W3135750489 cites W2142161929 @default.
• W3135750489 cites W2171227465 @default.
• W3135750489 cites W2214074259 @default.
• W3135750489 cites W2487704570 @default.
• W3135750489 cites W2963622568 @default.
• W3135750489 cites W2970463661 @default.
• W3135750489 cites W3009834387 @default.
• W3135750489 cites W3009912996 @default.
• W3135750489 cites W3012253443 @default.
• W3135750489 cites W3014233146 @default.
• W3135750489 cites W3016262285 @default.
• W3135750489 cites W3016489853 @default.
• W3135750489 cites W3020909574 @default.
• W3135750489 cites W3021761131 @default.
• W3135750489 cites W3022409537 @default.
• W3135750489 cites W3022504328 @default.
• W3135750489 cites W3024643080 @default.
• W3135750489 cites W3025271273 @default.
• W3135750489 cites W3025559601 @default.
• W3135750489 cites W3025587545 @default.
• W3135750489 cites W3025871232 @default.
• W3135750489 cites W3030576417 @default.
• W3135750489 cites W3036278922 @default.

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