FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3135752007> ?p ?o ?g. }

• W3135752007 endingPage "114000" @default.
• W3135752007 startingPage "114000" @default.
• W3135752007 abstract "In folk medicine, parts of Plumeria alba L. are used for the treatment of many diseases, with its latex being used for curing skin diseases and promoting wound healing.This study aimed to study the role of P. alba L. latex in hemostasis and platelet aggregation.The latex of P. alba L. was processed to remove waxes and enrich protein content, and the final extract was named Plumeria alba L. natant latex (PaNL). PaNL was analyzed for protease activity against casein. The type of protease in PaNL was identified by using protease inhibitors such as E-64, phenylmethylsulfonyl fluoride, ethylenediaminetetraacetic acid, and pepstatin A. Human fibrinogen, fibrin, and collagen types I and IV were subjected to hydrolysis with different concentrations of PaNL. The thrombin-like activity of PaNL was determined by analyzing its fibrinogen-clotting and procoagulant activities. The role of PaNL in platelet aggregation was also investigated. Its hemorrhagic and edema-inducing activities were evaluated in a mouse model. Phytochemical compounds were identified by gas chromatography-mass spectroscopy.The findings of casein/gelatin zymography confirmed that PaNL possesses protease activity. The results of the protease inhibition study indicated the presence of a cysteine-type protease(s) in PaNL. PaNL hydrolyzed the subunits of fibrinogen, fibrin, and collagen types I and IV. Its fibrin-degradation activity indicated that PaNL possesses plasmin-like activity. PaNL induced clotting of citrated human plasma within 3 min of incubation in the absence of CaCl2, indicating the presence of thrombin-like activity, which was further confirmed by the results of the fibrinogen-clotting assay. PaNL induced platelet aggregation in the absence of agonists. There was no hemolytic activity. Mice injected with PaNL did not show edema/ hemorrhagic activity.PaNL possesses procoagulant, fibrino(geno)lytic, thrombin- and plasmin-like activities and induces platelet aggregation, which could explain its usage for wound treatment in folk medicine." @default.
• W3135752007 created "2021-03-15" @default.
• W3135752007 creator A5000799570 @default.
• W3135752007 creator A5039793867 @default.
• W3135752007 creator A5041222646 @default.
• W3135752007 creator A5050666263 @default.
• W3135752007 creator A5087886011 @default.
• W3135752007 creator A5088507519 @default.
• W3135752007 date "2021-06-01" @default.
• W3135752007 modified "2023-09-23" @default.
• W3135752007 title "Thrombin- and plasmin-like and platelet-aggregation-inducing activities of Plumeria alba L. latex: Action of cysteine protease" @default.
• W3135752007 cites W1775749144 @default.
• W3135752007 cites W1976157905 @default.
• W3135752007 cites W1984064585 @default.
• W3135752007 cites W1985407614 @default.
• W3135752007 cites W1988132234 @default.
• W3135752007 cites W1989693372 @default.
• W3135752007 cites W1990097426 @default.
• W3135752007 cites W2018777979 @default.
• W3135752007 cites W2021288331 @default.
• W3135752007 cites W2022619070 @default.
• W3135752007 cites W2023042965 @default.
• W3135752007 cites W2024017659 @default.
• W3135752007 cites W2033621104 @default.
• W3135752007 cites W2034466002 @default.
• W3135752007 cites W2046645837 @default.
• W3135752007 cites W2048013243 @default.
• W3135752007 cites W2056097440 @default.
• W3135752007 cites W2058252463 @default.
• W3135752007 cites W2059331957 @default.
• W3135752007 cites W2059994793 @default.
• W3135752007 cites W2072668273 @default.
• W3135752007 cites W2078010779 @default.
• W3135752007 cites W2078958131 @default.
• W3135752007 cites W2081753893 @default.
• W3135752007 cites W2085575390 @default.
• W3135752007 cites W2089763203 @default.
• W3135752007 cites W2094637692 @default.
• W3135752007 cites W2100837269 @default.
• W3135752007 cites W2115821311 @default.
• W3135752007 cites W2123811384 @default.
• W3135752007 cites W2125731641 @default.
• W3135752007 cites W2159227170 @default.
• W3135752007 cites W2167928913 @default.
• W3135752007 cites W2313080488 @default.
• W3135752007 cites W2326152681 @default.
• W3135752007 cites W2326391152 @default.
• W3135752007 cites W2728750122 @default.
• W3135752007 cites W2887092547 @default.
• W3135752007 cites W810505861 @default.
• W3135752007 doi "https://doi.org/10.1016/j.jep.2021.114000" @default.
• W3135752007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33705919" @default.
• W3135752007 hasPublicationYear "2021" @default.
• W3135752007 type Work @default.
• W3135752007 sameAs 3135752007 @default.
• W3135752007 citedByCount "3" @default.
• W3135752007 countsByYear W31357520072021 @default.
• W3135752007 countsByYear W31357520072022 @default.
• W3135752007 crossrefType "journal-article" @default.
• W3135752007 hasAuthorship W3135752007A5000799570 @default.
• W3135752007 hasAuthorship W3135752007A5039793867 @default.
• W3135752007 hasAuthorship W3135752007A5041222646 @default.
• W3135752007 hasAuthorship W3135752007A5050666263 @default.
• W3135752007 hasAuthorship W3135752007A5087886011 @default.
• W3135752007 hasAuthorship W3135752007A5088507519 @default.
• W3135752007 hasConcept C177430391 @default.
• W3135752007 hasConcept C181199279 @default.
• W3135752007 hasConcept C185592680 @default.
• W3135752007 hasConcept C203014093 @default.
• W3135752007 hasConcept C2776142715 @default.
• W3135752007 hasConcept C2776714187 @default.
• W3135752007 hasConcept C2777292125 @default.
• W3135752007 hasConcept C54173615 @default.
• W3135752007 hasConcept C55493867 @default.
• W3135752007 hasConcept C86803240 @default.
• W3135752007 hasConcept C89560881 @default.
• W3135752007 hasConceptScore W3135752007C177430391 @default.
• W3135752007 hasConceptScore W3135752007C181199279 @default.
• W3135752007 hasConceptScore W3135752007C185592680 @default.
• W3135752007 hasConceptScore W3135752007C203014093 @default.
• W3135752007 hasConceptScore W3135752007C2776142715 @default.
• W3135752007 hasConceptScore W3135752007C2776714187 @default.
• W3135752007 hasConceptScore W3135752007C2777292125 @default.
• W3135752007 hasConceptScore W3135752007C54173615 @default.
• W3135752007 hasConceptScore W3135752007C55493867 @default.
• W3135752007 hasConceptScore W3135752007C86803240 @default.
• W3135752007 hasConceptScore W3135752007C89560881 @default.
• W3135752007 hasLocation W31357520071 @default.
• W3135752007 hasLocation W31357520072 @default.
• W3135752007 hasOpenAccess W3135752007 @default.
• W3135752007 hasPrimaryLocation W31357520071 @default.
• W3135752007 hasRelatedWork W1900331501 @default.
• W3135752007 hasRelatedWork W1991517410 @default.
• W3135752007 hasRelatedWork W2042124258 @default.
• W3135752007 hasRelatedWork W2063301225 @default.
• W3135752007 hasRelatedWork W2072272548 @default.
• W3135752007 hasRelatedWork W2088224313 @default.
• W3135752007 hasRelatedWork W2296946699 @default.

• next